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Population genomic evidence of Plasmodium vivax Southeast Asian origin


P. vivax originates from sub-Saharan Africa based on the circulation of its closest genetic relatives (
P. vivax-like) among African great apes. However, the limited number of genetic markers and samples investigated questions the robustness of this hypothesis. Here, we extensively characterized the genomic variations of 447 human
P. vivax strains and 19 ape
P. vivax-like strains collected worldwide. Phylogenetic relationships between human and ape
Plasmodium strains revealed that
P. vivax-like, not included within the radiation of
P. vivax-like. By investigating various aspects of
P. vivax genetic variation, we identified several notable geographical patterns in summary statistics in function of the increasing geographic distance from Southeast Asia, suggesting that ....

Coted Ivoire , Oromia Regional State , Ivory Coast , Centre National De , National Center , College Of Health , Animal Life Administration Of Libreville , Ministry Of Health , Oromia Regional State Health Bureau , National Hospital , Centers For Disease Control , French National Reference Centers , Ethical Clearance Committee Of The Haramaya University , Beckman Coulter , Centre International De Recherches , Saharan Africa , Southeast Asia , Saharan African , Cheikh Zayed Hospital , Action Sanitaire De Nouakchott , Centre National , Ethical Clearance Committee , Haramaya University , Medical Sciences , Animal Life Administration , Disease Control ,