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2 1Department of General Surgery, Shanghai Eighth People’s Hospital, Jiangsu University, Shanghai, People’s Republic of China; 2Department of General Surgery, Shanghai Eighth People’s Hospital, Shanghai, People’s Republic of China; 3Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China These authors contributed equally to this work Correspondence: Shengli Pan; Xianju Qin Department of General Surgery, Shanghai Eighth People’s Hospital, Caobao Road No. 8, Shanghai 200232, People’s Republic of China Tel +86-21-34284588 Introduction: Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. Copines-1 (CPNE1) has been shown to be overexpressed in various cancers; however, the role of CPNE1 in CRC remains unknown. Therefore, it is of great importance to elucidate the role of CPNE1 in CRC and its underlying mechanism of action. ....