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Using soft X-ray tomography for 3D imaging of cell structures in few minutes

Viral pathogens like the SARS-CoV-2 coronavirus change the interior structure of the cells they infect. These changes occur at the level of individual cell components – the organelles – and can provide information on how viral diseases develop. ....

Baden Wüberg , United States , Ralf Bartenschlager , Venera Weinhardt , Emily Henderson , German Research Foundation , European Research Council , Framework Programme Of The European Union , Centre For Organismal Studies , Heidelberg University Hospital , Heidelberg University , Organismal Studies , Lawrence Berkeley National Laboratory , Imaging Techniques , Ars Cov 2 , X Ray ,

Heidelberg researchers replicate rare genetic defect in fish model


Heidelberg researchers replicate rare genetic defect in fish model
A rare genetic defect that affects the so-called ALG2 gene can cause serious metabolic diseases in humans. It does so through the defective formation of proteins and sugar molecules. Until now, its rareness and complexity made it difficult to study this congenital glycosylation disorder.
A research team led by Prof. Dr Joachim Wittbrodt and Dr Thomas Thumberger from the Centre for Organismal Studies (COS) of Heidelberg University has finally succeeded in introducing the underlying mutation in the ALG2 gene in a fish model, thus allowing the causes of these complex diseases to be studied at the molecular level. ....

Joachim Wittbrodt , Thomas Thumberger , Emily Henderson , Centre For Organismal Studies , Heidelberg University , Organismal Studies , ஜேயொவாகிம் விட்திப்ரொடட் , எமிலி ஹென்டர்சன் , மையம் க்கு ஒர்கனிஸ்மால் ஆய்வுகள் , ஹைடெல்பெர்க் பல்கலைக்கழகம் , ஒர்கனிஸ்மால் ஆய்வுகள் ,