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Human organ chips enable COVID-19 drug repurposing

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A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the Institute s organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19.
The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the process of evaluating the safety and efficacy of existing drugs for new medical applications, and provides a proof-of-concept for the use of Organ Chips to rapidly repurpose existing drugs for new medical applications, including future pandemics. The research is reported in
Nature Biomedical Engineering.
While many groups around the world have been testing existing drugs for efficacy against COVID-19 using cultured cells, it is well known that cells grown in a dish do not behave like the cells in a living human body, and many drugs that appear effective in lab studies do not work ....

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Detailed text transcripts for TV channel - DW - 20180206:21:40:00

Been a huge rise in animal testing in germany alone three million so-called laboratory animals die in experiments every year. it s as though there were a basic principle in the industry no animal gets out of the lab alive more than two thirds of the animals used in laboratory tests are mice followed by rats fish rabbits and birds in the e.u. testing on non-human primates requires a special permit so they re used less frequently. and there are plenty of alternatives to take another example the berlin based company tissues makes miniaturize systems that simulate the activity of human organs the company s multi organ chips can reduce and replace animal tests in the lab. dozens of them with this is our multi organ chip it s basically a small bio reactor which combines four different organs in this case the skin the liver the intestine and the kidneys down. the artificial organs are ....

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