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Afamitresgene autoleucel as an effective T-cell therapy for synovial sarcoma and liposarcoma

1. Overall response rate to afami-cel in both groups was 37%. 2. The majority of adverse-events were moderate in nature with no treatment-related deaths. Evidence Rating Level: 1 (Excellent) Study Rundown: Synovial sarcoma and myxoid round cell liposarcoma are rare, chemo-refractory malignancies with a poor prognosis once metastasized. Current treatment regimens are limited, and a ....

United States , Rating Level , Advanced Alveolar Soft Part , Between Dec , Afamitresgene Autoleucel , Chimeric Antigen Receptor Cart Cell Therapy , Synovial Sarcoma , Chronic Disease ,

Pembrolizumab enhances progression-free survival in patients with locally advanced cervical cancer

1. Progression-free survival at 24 months was higher in the pembrolizumab versus placebo-controlled group. 2. The pembrolizumab-chemoradiotherapy group reported slightly higher rates of grade 3 or higher adverse events compared to the placebo-chemoradiotherapy group. Evidence Rating Level: 1 (Excellent) Study Rundown: Pembrolizumab has demonstrated efficacy in advanced cervical cancer, prompting an investigation into its potential ....

Rating Level , Response Evaluation Criteria , Solid Tumours , Metastatic Cervical , Between Jun , Cervical Cancer , Gynecologic Oncology , Locally Advanced Cervical Cancer , Chronic Disease ,

Breast cancer patients more likely to develop second cancer in lifetime: Study

Breast cancer patients more likely to develop second cancer in lifetime: Study
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United Kingdom , National Cancer Registration Dataset , Lancet Regional Health , University Of Cambridge , Lancet Regional Health Europe , Breast Cancer , Second Cancer , Increased Risk , On Breast Cancer , Contralateral Breast Cancer , Endometrial Cancer , Myeloid Leukemia , Ovarian Cancer ,

The addition of cisplatin to standard-of-care radiation therapy does not appear to improve progression-free survival for patients with localized recurrent endometrial cancer.

1. For patients with localized endometrial cancer recurrence, adding cisplatin to radiation therapy did not appear to improve progression-free survival when compared to radiation therapy alone. 2. For patients with localized endometrial cancer recurrence, adding cisplatin to radiation therapy resulted in higher rates of acute toxicity, when compared to radiation therapy alone. Evidence Rating Level: ....

Rating Level , Endometrial Cancer , Chronic Disease ,