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Data describe induced pluripotent stem cell -derived excitatory neurons as a human model for assessing selectivity of drug binding to soluble amyloid beta oligomers in Alzheimer’s diseaseResults. | March 28, 2023 ....
Lignin is arguably the most abundant component of biomass that most people have never heard of. That may be about to change. Many people are familiar with its biochemical cousin cellulose, a bypr . ....
In a continuation to better understand cascade reactions of indigo 1 and generate new heterocycles, a series of electron-rich and electron-deficient indigos were targeted to evaluate the effects of electronics upon the outcome. The synthesis of methoxy-, bromo- and phenyl-substituted indigos 120, 124, 145 – 147, 149 and 164 was achieved in modest to good yields (22 – 58%) in one step according to the Baeyer-Drewson synthesis. Access to 5,5'- and 6,6'-dinitroindigos 148 and 150 was achieved through the hydrolysis of 3-acetoxy-5-nitroindole 154 and the Baeyer-Drewson synthesis, respectively, though an additional Boc-protection and deprotection was required to purify these derivatives. The isolation of novel N,N',O,O'-tetraBoc-5,5'- and 6,6'-dinitroindigos 157 and 170 as minor by-products (1%) in these syntheses required a 2 e- reduction, suggesting the electron-deficient nature of the dinitroindigos 148 and 150 may enable reductive processes to occur wit ....
Salad boxes to go, sealed-tray lasagna and apple juice in PET bottles: we encounter packaged food and drink everywhere. A new database shows which packaging contains harmful substances that can be . ....
Did Darwinian evolution begin before life itself? chemeurope.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from chemeurope.com Daily Mail and Mail on Sunday newspapers.