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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , United Kingdom , South Lanarkshire , Agarose Qiagen , Kapa Hyperprep , Tek Sakura Finetek , Astrazeneca Oxford , Fluospheres Neutravidin , Picard Markduplicates , Micromount Leica , Cytofix Cytoperm , Broad Institute , Immunospot Software Cellular Technology , Kapa Library Quant , Institutional Biosafety Committee , Gamaleya Research Institute , Accreditation Of Laboratory Animal Care , Agilent Technologies , Department Of Health , Beckman Coulter , Cellular Technology , Association For Assessment , Influenza Research , Roche Sequencing Solutions Inc , Committee At Rocky Mountain Laboratories , Laboratory Animals ,

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United Kingdom , United States , Sanofi Pasteur , Luminex Microplex , Jackson Immunoresearch , Kit Alpha Diagnostics International , Bioqual Inc , National Institute Of Allergy , Rnazol Bd Column Kits Molecular Research Center , Ragon Institute , Treestar Inc , European Union , Seromyx Systems Inc , Scripps Research Institute , Vaccine Research Center , Infections Research Resources Repository , Human Kidney Injury Magnetic Bead Panel , Biomedical Advanced Research , National Institutes Of Health , World Health Organization , Drug Administration , Development Authority , Peptide Technologies Inc , Luminex Corporation , Intramural Research Program , Rnazol Bd Molecular Research Center ,

B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes

Abstract
Cancer immunotherapy with 4-1BB agonists has limited further clinical development because of dose-limiting toxicity. Here, we developed a bispecific antibody (bsAb; B7-H3×4-1BB), targeting human B7-H3 (hB7-H3) and mouse or human 4-1BB, to restrict the 4-1BB stimulation in tumors. B7-H3×m4-1BB elicited a 4-1BB–dependent antitumor response in hB7-H3–overexpressing tumor models without systemic toxicity. BsAb primarily targets CD8 T cells in the tumor and increases their proliferation and cytokine production. Among the CD8 T cell population in the tumor, 4-1BB is solely expressed on PD-1 ....

United States , South Korea , Republic Of Korea , Tonbo Biosciences , Eomes Dan , Spectrostar Nano , Cytofix Cytoperm , Lab Inc , Ge Healthcare Life Sciences , Biocytogen Haimen Animal Center , Korean Cell Line Bank , Cell Signaling Technology , Treestar Inc , Precisionx Ray Inc , Donga St Co , Ge Healthcare , Ministry Of Education , Graphpad Prism Software , Biotech Center , Jiangsu Biocytogen Co , Tp Bio Co , Orient Bio Inc , Bio Inc , University Of Ulsan , Biacore Insight Evaluation Software Cytiva , Biocytogen Co ,

Early Release - Role of Burkholderia pseudomallei–Specific IgG2 in Adults with Acute Melioidosis, Thailand - Volume 27, Number 2—February 2021 - Emerging Infectious Diseases journal

Melioidosis is a life-threatening infectious disease caused by the gram-negative bacillus
Burkholderia pseudomallei. An effective vaccine is needed, but data on protective immune responses in human melioidosis are lacking. We used ELISA and an antibody-dependent cellular phagocytosis assay to identify the major features of protective antibodies in patients with acute melioidosis in Thailand. We found that high levels of
B. pseudomallei–specific IgG2 are associated with protection against death in a multivariable logistic regression analysis adjusting for age, diabetes, renal disease, and neutrophil count. Serum from melioidosis survivors enhanced bacteria uptake into human monocytes expressing FcγRIIa-H/R131, an intermediate-affinity IgG2-receptor, compared with serum from nonsurvivors. We did not find this enhancement when using monocytes carrying the low IgG2–affinity FcγRIIa-R131 allele. The findings indicate the importance of IgG2 in protection against death in ....

Krung Thep Mahanakhon , Eteläuomen Läi , Ubon Ratchathani , Miltenyi Biotec , Becton Dickinson , Graphpad Software Inc , International Conference On Harmonization Good Clinical Practice , Us Centers For Disease , Windows Statacorp , Oxford Tropical Research Ethics Committee , Roswell Park Memorial Institute , Mahidol Oxford Tropical Medicine Research Unit , Mahidol University , Disease Control , Tropical Medicine , Sunpasithiprasong Hospital , International Conference , Harmonization Good Clinical Practice , Assay Kit , Thermo Fisher Scientific , Nunc Maxisorp , Applied Biosystems , Fixation Buffer , Running Buffer , Mann Whitneyu Test , Graphpad Prism Version ,