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A team of scientists from Brazil recently explored the abilities of the UK, South African, and Brazilian variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to evade host CD8+ T cell responses induced by natural infection or vaccination. The findings reveal reduced antigenic coverage for the P.2 Brazilian lineage, indicating its ability to evade SARS-CoV-2-induced T cell responses. ....
Researchers continue to achieve a better understanding of SARS-CoV-2, the virus behind the ongoing COVID-19 pandemic. One such effort has been reported in a new preprint on the bioRxiv server, dealing with the phenomenon of backtracking. ....
The SARS-CoV-2 pathogen successfully uses multiple immune evasion mechanisms to achieve infection within its host. An intriguing new study describes one such process, which may help develop drugs to counteract the virus more effectively. ....
RNA editing events influence gene expression and phenotypic manifestation Combining computational mining of big data with experimental testing in the lab, researchers at Children s Hospital of Philadelphia (CHOP) have identified RNA editing events that influence gene expression and, in turn, the phenotypic manifestation of that expression. In analyzing so-called A-to-I RNA editing, in which the adenosine of an RNA molecule is chemically modified into an inosine, the researchers describe how a single nucleotide change by RNA editing can have large downstream effects. The findings were published today in Genome Biology. Millions of A-to-I RNA editing sites have been identified across the human transcriptome, but the functions of most RNA editing events are unknown. Understanding how RNA editing affects gene expression and phenotype could help us unravel the genetic basis to many human conditions. ....
How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection? Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The presence of antibodies against SARS-CoV-2 in individuals who contracted COVID-19 has been well documented. Research suggests that in the majority of cases, anti-SARS-CoV-2 antibodies can persist for six months or more in those who recover from COVID-19. However, reinfection has also be observed in many individuals across all age groups. Further, the severity of the infection was also found to vary across cases. With regard to SARS-CoV-2 reinfection cases, not many studies are available on viral characteristics, degree of sequence heterogeneity, and the point of mutation. The location of the mutation point can be determined by comparing the reference sequence with the reinfecting variants. Physicians are encountering an increase in the number of cases associate ....