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Study exploits biomolecular condensates to inhibit androgen receptor in prostate cancer

Transcription factors play essential roles in turning the genetic information encoded in genes into proteins in all cells and organisms. ....

Comunidad Autonoma De Cataluna , United Kingdom , Xavier Salvatella , Paula Mart , Marianne Sadar , Denes Hnisz , Marianned Sadar , Shaon Basu , Judit Anido , Mateusz Biesaga , University Of Barcelona , Bc Cancer University Of British Columbia , Max Planck Institute For Molecular Genetics , Institute For Research , Antoni Riera , Max Planck Institute , Molecular Genetics , British Columbia , Nuage Therapeutics , Nature Structural , Molecular Biology , Prostate Cancer , Transcription Factors , Molecular Biology ,

Targeting the Androgen Receptor More Effectively in Prostate Cancer

Targeting the Androgen Receptor More Effectively in Prostate Cancer
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United Kingdom , Comunidad Autonoma De Cataluna , Xavier Salvatella , Paula Mart , Denes Hnisz , Marianne Sadar , Judit Anido , Shaon Basu , Mateusz Biesaga , Institute For Research , University Of Barcelona , University Of British Columbia , Max Planck Institute For Molecular Genetics , Nature Structural , Max Planck Institute , Molecular Genetics , Antoni Riera , British Columbia , Molecular Biology , Nuage Therapeutics ,

Hard to drug: Protein droplets reveal new way

<ul>
<li>Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.</li>
<li>An international team of researchers from the Institute for Research in Biomedicine (IRB Barcelona), the Max Planck Institute for Molecular Genetics (MPIMG), BC Cancer (University of British Columbia) and other institutions has discovered a potential way to target the androgen receptor, the most prominent oncogenic transcription factor in prostate cancer, based on its propensity to form droplets also known as condensates.</li>
<li>The results described in this publication set the basis for the foundation of Nuage Therapeutics, a spinoff of IRB Barcelona and ICREA.</li>
<li>The findings are published in <em>Nature Structural & Molecular Biology</em>.</li>
</ul>
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Comunidad Autonoma De Cataluna , United Kingdom , Judit Anido , Denes Hnisz , Marianne Sadar , Shaon Basu , Mateusz Biesaga , Paula Mart , Marianned Sadar , Xavier Salvatella , University Of Barcelona , Max Planck Institute For Molecular Genetics , Bc Cancer University Of British Columbia , Institute For Research , Max Planck Institute , Molecular Genetics , British Columbia , Nuage Therapeutics , Nature Structural , Antoni Riera , Molecular Biology ,