Mucopolysaccharidosis VI (MPS VI) is an autosomal recessive lysosomal storage disease caused by mutations in the arylsulfatase B gene (ARSB) and consequent deficient activity of ARSB, a lysosomal enzyme involved in glycosaminoglycan (s) (GAGs) metabolism. Here we present the results study of ARSB DNA analysis in MPS VI patients in the Russian Federation (RF) and other republics of Former Soviet Union. In a cohort of 68 patients (57 families) with MPS VI, a total of 28 different pathogenic alleles were found. The most prevalent nucleotide changes included c.194C>T (Ser65Phe) and c.454C>T (Arg152Trp). Five pathogenic alleles were novel, not previously reported (с.304C>G, c.533A>G, c.941T>C, c.447 456del10, С.990 1003del14). The nucleotide variant c.454C>T (Arg152Trp) was prevalent allele among Slavic Russian patients. The nucleotide variant c.194C>T (Ser65Phe) was found only in MPS VI families from the Republic of Dagestan. Based on the analysis of dry blood spots
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panicked congress reskon veened and passed it. at least in all of those cases there was some external crisis present. what we have seen from this particular republican congressional class is a novel mutation of crisis government which is not to react to external crisis but to create, even in crises, in order to there by restrict what the political system can produce. we saw this before the new republican congress was with ever sworn in. right after the 2010 mid-term elections, during the lame duck session of congress. republicans threatened any help for the unemployed at a time of 9. % unemployment and threatened to put people on the street on christmas eve if they didn t get their way. they essentially created this crisis in order to preserve the bush tax cuts that were set to expire that month. a self-created crisis, but it worked. in april, another crisis. a potential government shutdown.