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Blocking Notch signaling pathway could reverse age-related bone loss

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice. ....

New York , United States , Christopher Park , Aristotelis Tsirigos , Ralf Adams , Philipp Leucht , Lukasz Witek , Mohamed Ali , Danielle Ellis , Backialakshmi Dharmalingam , Sophie Morgani , Paulo El Parente , Vasudev Nayak , Malissa Ramsukh , Ziyan Lin , Lauren Gillinov , Kevin Leclerc , Alesha Castillo , Sooyeon Lee , National Institutes Of Health , Langone Health , York Stem Cell Foundation , York University College Of Dentistry , Max Planck Institute For Molecular Biomedicine , Bone Research , Department Of Molecular Pathobiology ,

New treatment approach shows promise in reversing hormone resistance in breast cancer

A collaborative study between LSU Health New Orleans School of Medicine, the University of Rochester and Cellestia Biotech AG, a biopharmaceutical company headquartered in Basel, Switzerland, provides compelling evidence that combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases Rx effectiveness in experimental models of estrogen-receptor positive (ER+) and triple-negative breast cancers (TNBC), respectively. ....

United States , Jovanny Zabaleta , Giulia Monticone , Fokhrul Hossain , Luis Del Valle , Samarpan Majumder , Dorota Wyczechowska , Danielle Ellis , Lucio Miele , University Of Rochester , Health New Orleans School Of Medicine , Health New Orleans , New Orleans School , Cellestia Biotech , Senior Author , Assistant Dean , Translational Science , Assistant Professor , African American , New Orleans , Luis Del , Cancer Crusaders Chair , Breast Cancer , Notch Signaling ,

Experimental antibody treatment shows promise for preventing bone marrow transplant complication

An experimental antibody treatment largely prevented a bone marrow transplant complication called graft versus host disease (GVHD) in the intestines, without causing broad immune suppression, in a preclinical study led by researchers from Penn Medicine and Dana-Farber/Boston Children's Cancer and Blood Disorders Center and published today in Science Translational Medicine. ....

United States , Lily Ramsey , Eric Perkey , Ashley Vanderbeck , Leslies Kean , Ivan Maillard , Regeneron Inc , Perelman School Of Medicine , Be The Match Foundation , University Of Michigan , Leukemia Lymphoma Society , Blood Disorders Center , Pediatrics At Harvard Medical School , University Of Pennsylvania , National Institutes Of Health , Amy Strelzer Manasevit Research Program , Penn Medicine , Boston Children , Science Translational , Perelman School , Harvard Medical School , Pediatric Stem Cell Transplant , Victor Tkachev Phd , Mass General Brigham , Boston Childrens , Lymphoma Society ,

Incurable liver disease could be reversed with a single drug

Research led by Associate Professor Duc Dong, Ph.D., has shown for the first time that the effects of Alagille syndrome, an incurable genetic disorder that affects the liver, could be reversed with a single drug. ....

Chengjian Zhao , Sanford Burnham Preby , Roberta Smith , Emily Henderson , Proceedings Of The National Academy Sciences , Alagille Syndrome Alliance , Associate Professor Duc Dong , National Academy , Alagille Syndrome , Industry Focus , Alagille Syndrome , Genetic Disorder , Notch Signaling , Rare Disease ,

NovAccess Global Announces Fireside Chat with Board Member Perspectives

NovAccess Global Announces Fireside Chat with Board Member Perspectives - read this article along with other careers information, tips and advice on BioSpace ....

United States , San Diego , Dwain Irvin , Anders Bjorklund , Jason Anderson , Christopher Wheeler , John Cassarini , Ingalls Snyder , University Of California , School Of Medicine , London School Of Economics , Darrow Associates , Travelers Corporation , Lehman Brothers , Edenroc Sciences , Equity Research Department Of Smith Barney , Masters In Public Health , Novaccess Global Inc , Securities Exchange Commission , Sinai Medical Center , Company Board Of Directors , Health Science , Fordham University , Barclays Capital , Liberty Biosecurity , School Of Public Health ,