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Florian Naudet and colleagues argue that routine registration of observational research is needed and suggest how current processes can be adapted to facilitate it From the use of booster doses against covid-191 to approval of novel cancer therapies,2 health authorities and health technology assessment bodies are increasingly relying on non-randomised trials and observational studies. The methodological problems of observational studies, such as residual confounding,3 are difficult to resolve, but concerns about transparency and reliability can be reduced through registration. Registration is an open science practice whereby research hypotheses, elements of study design, and planned statistical analyses are prespecified, preferably in a centralised repository. Registration has become the norm for clinical trials (interventional studies),4 and some have called for it to be adopted for observational studies.56 However, opponents argue that systematic registration is unrealistic, unnece

Florian naudetNicholasj devitoChiragj patelAlain braillonLe goffIoanaa cristeaSabine hoffmann