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"Cannabidiol as a Treatment for Neurobiological, Behavioral, and Psycho" by Jessica G. Bartschi, Lisa Marie Greenwood et al.

Rationale: The slowing of disease progression in dementia in the early stages of diagnosis is paramount to improving the quality of life for those diagnosed and their support networks. Accumulating evidence suggests that CBD, a constituent of Cannabis sativa, is associated with neuroprotective, neuroendocrine, and psychotherapeutic effects, suggesting that it may be beneficial to dementia treatment. However, no published human study to date has examined this possibility. This trial aims to determine whether daily treatment with CBD over a 12-week period is associated with improved neurobiological, behavioral, and psychological outcomes in individuals living with early-stage dementia. Methods: Sixty participants with early-stage dementia will be recruited for a randomized, double-blind, placebo-controlled clinical trial. Participants will be randomized into either 99.9% pure CBD or placebo treatment conditions and administered two capsules per day for 12 weeks. Participants will commenc ....

Therapeutic Goods Administration , New Zealand Clinical Trials Registry , Behavioral And Psychological Symptoms Of Dementia Bpsd , Clinical Trial ,

"A blended professional learning intervention for early childhood educa" by Peden Me, Eady Mj et al.

Background: Childcare centres are important environments for promoting physical activity and healthy eating. Blended approaches to professional learning may help overcome existing challenges for educators in promoting these behaviours. This study aimed to test the effect of a blended professional learning program on healthy eating and physical activity in childcare. Methods: Cluster randomized stepped-wedge trial in 15 childcare centres in Tasmania, Australia. Children aged 2-5y who attended at least two days per week were eligible to participate. Random assignment occurred at the centre level. Centre names were drawn out of a hat and then subsequently allocated to one of the three steps. The intervention comprised a 12-week blended professional learning program for educators. The main outcome was centre-level physical activity and healthy eating, assessed using the Environment and Policy Assessment Observation System (EPAO). All data collectors were blinded to step allocation. Analyse ....

Policy Assessment Observation System , Australian New Zealand Clinical Trial Registry , New Zealand Clinical Trials Registry , Blended Professional Learning , Early Childhood Education And Care , Healthy Eating , Physical Activity ,