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Rehabilitation plus stem cell grafting after spinal cord injury can augment functional outcomes

In recent years, researchers have made measurable progress, using animal models, to promote tissue regeneration in spinal cord injuries (SCI) through implanted neural stem cells or grafts. Other efforts have shown that intensive physical rehabilitation can improve function after SCI by promoting greater or new roles for undamaged or spared cells and neural circuits. ....

San Diego , United States , University Of California San Diego , Ashley Villarta , Amandan Tran , J Russell Huie , Emily Henderson , Paul Lu , Adamr Ferguson , Markh Tuszynski , Lori Graham , Dena Yassin , Translational Neuroscience Institute , Veterans Administration , Veterans Administration Medical Center , Adelson Biomedical Research Foundation , Craigh Nielsen Foundation , Veterans Administration San Diego Healthcare System , Uc San Diego School Of Medicine , California San Diego School , Diego School , Veterans Administration San Diego Healthcare , Industry Focus , Camila Marques De Freria , Gordon Mansfield Consortium , Spinal Cord Injury Research ,

Researchers propose guidelines and methods for consistently generating high-quality brain organoids

By using stem cells to grow miniature brain-like organs in the lab, scientists have opened a new avenue for studies of neurological development, disease and therapies that can't be conducted in living people. ....

United States , Momoko Watanabe , Bennett Novitch , Kathrin Plath , Amander Clark , Emily Henderson , Brain Research Institute Integrated Center , Stem Cell Research , California Institute For Regenerative Medicine , Brain Research Institute , Broad Stem Cell Research Center , Sue Bill Gross Stem Cell Research Center , Rose Hills Foundation , National Institutes Of Health , Jonsson Comprehensive Cancer Center , Ablon Scholars Program , Uehara Memorial Foundation , Edythe Broad Center , Howard Hughes Medical Institute , Wild West , Regenerative Medicine , Stem Cell Reports , Research Institute , Integrated Center , Genomics Industry Focus , Bill Gross Stem Cell Research ,

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development. ....

United States , San Diego , Ardem Patapoutian , Medha Pathak , Jamison Nourse , Emily Henderson , University Of California , Scripps Research Institute , School Of Medicine , National Institutes Of Health , Department Of Physiology Biophysics , Assistant Professor , Nobel Prize , National Institutes , Ton Channel , Neural Stem Cells , Neurodegenerative Diseases , Stem Cells ,

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

The axolotl Ambystoma mexicanum is a popular pet due to its unique and cute appearance. Unlike other salamanders undergoing metamorphosis, axolotls (pronounced ACK-suh-LAH-tuhl) never outgrow their larval, juvenile stage, a phenomenon called neoteny. ....

Xiaoyu Wei , Xun Xu , Emily Henderson , Life Sciences , Neural Stem Cells , Progenitor Cells , Stem Cells ,

Increasing the production of new neurons rescues memory defects in mice with Alzheimer's disease

Researchers at the University of Illinois Chicago have discovered that increasing the production of new neurons in mice with Alzheimer's disease (AD) rescues the animals' memory defects. ....

United States , Emily Henderson , University Of Illinois Chicago , University Of Illinois Chicago College Medicine , Department Of Anatomy , Illinois Chicago , Experimental Medicine , Orly Lazarov , Cell Biology , Illinois Chicago College , Lzheimer 39s Disease , Cell Biology , Neural Stem Cells , Stem Cells ,