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Botched J&J Vax Batch; More Pfizer Efficacy Boasts; New OTC Tests OK'd

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One of Johnson & Johnson s contract vaccine manufacturers messed up during production of 15 million doses, putting shipments behind schedule. (
New York Times)
Meanwhile, Pfizer and BioNTech said their vaccine was 100% effective in South Africa, where the troubling B.1.351 variant is widespread, amidst other boasts about the product.
France will undergo a third national lockdown through the end of April due to accelerating coronavirus spread. (
NPR)
As of Thursday at 8:00 a.m. EDT, the unofficial COVID-19 toll reached 30,461,066 cases and 552,073 deaths reflecting increases of 66,878 and 1,075, respectively, over the previous 24 hours.
In 2020, COVID-19 was the third leading cause of death in the U.S., according to the CDC; during some weeks, it was responsible for one-quarter of all deaths. ....

United States , New York , South Africa , Peter Navarro , Sarah Palin , New York Times , Kaiser Health News , Washington Post , European Medicines Agency , National Bureau Of Economic Research , National Bureau , Economic Research , President Trump , Attention Deficit Hyperactivity Disorder , Combined Type , Malignant Adenomatous Neoplasm , Mass Of Body Structure , Neoplastic Disease , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் , பீட்டர் நேவாரு , புதியது யார்க் முறை , கைசர் ஆரோக்கியம் செய்தி , வாஷிங்டன் போஸ்ட் , தேசிய பணியகம் ஆஃப் பொருளாதார ஆராய்ச்சி , தேசிய பணியகம் ,

Weight-Loss Surgery and Cancer; Testosterone and Melanoma; Cancer and Clot Risk

Rutgers Robert Wood Johnson Medical School,
Gastroenterology)
University of Gothenburg, PLOS One)
The FDA and its European counterpart have agreed on a template for streamlining development and approval of new drugs for pediatric cancers. (
Endpoints News)
Bristol Myers Squibb announced that a phase III trial of the anti-LAG-3 antibody relatlimab plus nivolumab (Opdivo) met the primary endpoint of improved progression-free survival in patients with previously untreated unresectable or metastatic melanoma.
Overall survival and progression-free survival improved significantly in patients with metastatic hormone receptor-positive,
HER2-negative breast cancer treated with frontline palbociclib (Ibrance) and letrozole, according to a statement from Pfizer. ....

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Practice Change Needed for Gastroesophageal Cancer?

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Treatment with pembrolizumab (Keytruda) improved survival for patients with microsatellite instability-high (MSI-H) gastric or gastroesophageal junction (GEJ) cancer, irrespective of the number of prior therapies, a retrospective analysis of three clinical trials suggested.
The median overall survival (OS) with pembrolizumab-containing therapy was not reached in the MSI-H subgroup in any of the trials, which involved previously treated and untreated patients. Median progression-free survival (PFS) was not reached in a noncomparative trial and exceeded median PFS with chemotherapy in the two randomized trials.
Pembrolizumab alone or in combination with chemotherapy led to higher response rates versus chemotherapy, Joseph Chao, MD, of City of Hope in Duarte, California, and coauthors reported in ....

United States , Fox Chase Cancer Center , Joseph Chao , Charles Bankhead , Efrat Dotan , Arishi Jain , Medpage Today , Malignant Adenomatous Neoplasm , Mass Of Body Structure , Neoplastic Disease , ஒன்றுபட்டது மாநிலங்களில் , நரி துரத்து புற்றுநோய் மையம் , ஜோசப் குழப்பம் , சார்லஸ் வங்கித் தலை , ரிஷி ஜெயின் , நிறை ஆஃப் உடல் அமைப்பு ,

Pre-Op CRT Promising in Locally Advanced Esophageal SCC

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Neoadjuvant chemoradiotherapy (CRT) held its own on safety outcomes in a head-to-head trial against neoadjuvant chemotherapy alone for locally advanced esophageal squamous cell carcinoma (SCC), an interim analysis of a randomized study from China found.
In the multicenter trial of more than 250 patients going on to minimally invasive surgery, the two approaches yielded similar rates of perioperative morbidity and mortality, as well as similar survival at 1 year, but significant histopathologic advantages emerged for the group receiving neoadjuvant CRT, reported Lijie Tan, MD, of Fudan University in Shanghai, and colleagues.
While more and more evidence has suggested the survival benefit from neoadjuvant therapy followed by surgery for locally advanced esophageal cancer, only three trials have directly compared neoadjuvant CRT and chemotherapy in this setting, the group wrote in ....

Li Jie , Marcog Patti , Fernandoam Herbella , Ian Ingram , Fudan University , University Of North Carolina , Lijie Tan , Escola Paulista De Medicina , North Carolina , Chapel Hill , Medpage Today , Deputy Managing Editor , Neoplastic Disease , Spinal Cord Compression , Squamous Cell Carcinoma , லி ஜிே , ஈயந் இஂக்ரம் , பல்கலைக்கழகம் ஆஃப் வடக்கு கரோலினா , எஸ்கோலா போஉலிஸ்த்ா டி மருத்துவ , வடக்கு கரோலினா , தேவாலயம் மலை , துணை நிர்வகித்தல் ஆசிரியர் , முதுகெலும்பு தண்டு சுருக்க ,

Accelerated Approvals Scrutinized; Cancer and Vaccine Hesitancy; Sugary Drink Risk

News, features, and commentary about cancer-related issues ....

United States , City Of , United Kingdom , Charles Bankhead , King College London , American Society Of Hematology , Saint Barnabas Medical Center , Leukemia Lymphoma Society , National Comprehensive Cancer Network , University At Buffalo , Endpoints News , College London , Lymphoma Society , Science Kite , American Society , Therapeutic Innovation , Regulatory Science , Medpage Today , Neoplastic Disease , Mass Of Body Structure , ஒன்றுபட்டது மாநிலங்களில் , நகரம் ஆஃப் , ஒன்றுபட்டது கிஂக்டம் , சார்லஸ் வங்கித் தலை , கிங் கல்லூரி லண்டன் , அமெரிக்கன் சமூகம் ஆஃப் ஹீமாட்டாலஜி ,