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SARS-CoV-2 'frameshifting' could be a critical weakness


Inhibiting the process would significantly reduce viral replication in infected cells.
Viruses require the resources of an infected cell to replicate and then infect further cells, and transfer to other individuals. One essential step in the viral life cycle is production of new viral proteins based on the instructions in the viral RNA genome. Based on these construction plans, the cell’s own protein synthesis machine, called the ribosome, produces the viral proteins.
The dependence of SARS-CoV-2 on this ribosomal frameshifting event could be used to develop antiviral drugs.
In the absence of viral infection, the ribosome moves along the RNA in strictly defined steps, reading three letters of RNA at a time. This three-letter code defines the corresponding amino acid that attaching to the growing protein. It almost never happens that the ribosome slips one or two RNA letters forward or backward instead of following the regular three-letter steps. When such a slip of t ....

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