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Scientists Create First-of-its-Kind 3D Organoid Model of Human Pancreas

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Scientists Create First-of-its-Kind 3D Organoid Model of Human Pancreas
New Research Platform Will Shed Light on the Early Stages of Pancreatic Cancer and Could Open the Door to Life-Saving Screening
Boston – This year, more than 60,000 adults in the United States will be diagnosed with pancreatic cancer and, statistically, as few as 10 percent will survive five years after diagnosis, according to the American Cancer Society. Because pancreatic cancer is hidden deep within the body and often symptomless, it’s frequently diagnosed after the disease has progressed too far for surgical intervention and/or has spread throughout the body. Research indicates that earlier detection of pancreatic tumors could quadruple survival rates; however, no validated and reliable tests for early detection of pancreatic cancer currently exist. ....

United States , Harvard University , Lakshmib Muthuswamy , Dipikaa Akshinthala , Doug Melton , Ridhdhi Desai , Raul Gonzalez , Danieln Conrad , Senthil Muthuswamy , Zev Gartner , Nayara Carvalho Leite , Cancer Research Institute , Harvard Medical School , Research Platform , University Of California San Francisco , Hirschberg Foundation For Pancreatic Cancer Research , American Cancer Society , New Research Platform Will Shed Light , Early Stages , Pancreatic Cancer , Could Open , American Cancer , Beth Israel Deaconess Medical Center , Cell Biology , Ling Huang , Associate Professor Medicine ,

Scientists create first-of-its-kind 3D organoid model of the human pancreas

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Boston - This year, more than 60,000 adults in the United States will be diagnosed with pancreatic cancer and, statistically, as few as 10 percent will survive five years after diagnosis, according to the American Cancer Society. Because pancreatic cancer is hidden deep within the body and often symptomless, it s frequently diagnosed after the disease has progressed too far for surgical intervention and/or has spread throughout the body. Research indicates that earlier detection of pancreatic tumors could quadruple survival rates; however, no validated and reliable tests for early detection of pancreatic cancer currently exist.
Now, researchers at the Cancer Research Institute at Beth Israel Deaconess Medical Center (BIDMC) have successfully created the first three-dimensional (3D) organoid models of the pancreas from human stem cells. Unlike previous platforms for the study of pancreatic cancer, this first-of-its-kind organoid model includes both the acinar and ....

United States , Harvard University , Lakshmib Muthuswamy , Dipikaa Akshinthala , Doug Melton , Ridhdhi Desai , Raul Gonzalez , Danieln Conrad , Senthil Muthuswamy , Zev Gartner , Nayara Carvalho Leite , Cancer Research Institute , University Of California San Francisco , Harvard Medical School , Hirschberg Foundation For Pancreatic Cancer Research , American Cancer Society , American Cancer , Beth Israel Deaconess Medical Center , Cell Stem , Cell Biology , Ling Huang , Associate Professor Medicine , Harvard Medical , Research Fellow , Christine Maria Lim , California San Francisco ,