It will be located at the Tilling Green Community Centre in Mason Road.
The facility will be launched tomorrow (Thursday, May 27), organisers said.
Anthony Kimber, leader of Rye Emergency Action Community Team (REACT), said: “Since the start of the vaccination programme people in Rye and district have mostly had to travel 20 miles to Etchingham for jabs.
The new vaccination centre will be at the Tilling Green Community Centre SUS-210524-130817001
“As a result, we have been discussing with the NHS at various levels the possibility of providing a vaccination facility closer to Rye. Work has had the support of MP Sally-Ann Hart and Rye Mayor, Cllr Rebekah Gilbert.