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Strategy overcomes EZH2 inhibitor resistance in SMARCB1 mutated cancer

Strategy overcomes EZH2 inhibitor resistance in SMARCB1 mutated cancer
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Yiannis Drosos , Taosheng Chen , Charles Roberts , Emma Beane , Margaret Larsen , Santhosh Upadhyaya , Natarajan Bhanu , Charles Wm Roberts , Sandi Radko Juettner , Jacquelyn Myers , Baranda Hansen , Sandeep Dhanda , Robert Mobley , Janet Partridge , Xiaotu Ma , Benjamin Garcia , Samuel Peters , Shondra Pruett Miller , Kaeli Mathias , Broad Institute , Jude Oncology Department , National Cancer Institute , Jude Children Research Hospital , Garretb Smith Foundation , Drug Administration , Jude Comprehensive Cancer Center ,

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. ....

Yiannis Drosos , Taosheng Chen , Emma Beane , Margaret Larsen , Emily Henderson , Santhosh Upadhyaya , Natarajan Bhanu , Charles Wm Roberts , Sandi Radko Juettner , Jacquelyn Myers , Baranda Hansen , Sandeep Dhanda , Robert Mobley , Janet Partridge , Xiaotu Ma , Benjamin Garcia , Samuel Peters , Shondra Pruett Miller , Kaeli Mathias , Broad Institute , Jude Oncology Department , National Cancer Institute , Jude Children Research Hospital , Garretb Smith Foundation , Drug Administration , Jude Comprehensive Cancer Center ,