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Frontiers | An Update on Protective Effectiveness of Immune Responses After Recovery From COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits variable immunity responses among hosts based on symptom severity. Whether immunity in recovered individuals is effective for avoiding reinfection is poorly understood. Determination of immune memory status against SARS-CoV-2 helps identify reinfection risk and vaccine efficacy. Hence, after recovery from COVID-19, evaluation of protective effectiveness and durable immunity of prior disease could be significant. Recent reports described the dynamics of SARS-CoV-2 -specific humoral and cellular responses for more than six months in convalescent SARS-CoV-2 individuals. Given the current evidence, NK cell subpopulations, especially the memory-like NK cell subset, indicate a significant role in determining COVID-19 severity. Still, the information on the long-term NK cell immunity conferred by SARS-CoV-2 infection is scant. The evidence from vaccine clinical trials and observational studies indicates that hybrid natural/ ....

Eastern Cape , South Africa , Western Cape , Saudi Arabia , United Kingdom , South Korea , Free State , Yunbao Pan , Paige Lawrence , Zhengm Tim , Cohen Tervaert , Cullym Exosome , Jernbom Falk , Nasrin Shokrpour , Shiraz University Of Medical Science , Health Sci , Terminal Differentiation Of Plasma Cells In Health , Shiraz University Of Medical Sciences , Development Of Clinical Research Nemazee Hospital , S Specific Igg , Natural Immunity , Vaccine Immunity , Shiraz University , Medical Science , Medical Sciences , Clinical Research ,

Frontiers | Healthcare Workers in South Korea Maintain a SARS-CoV-2 Antibody Response Six Months After Receiving a Second Dose of the BNT162b2 mRNA Vaccine

Background: Effective vaccines against coronavirus disease 2019 (COVID-19) are available worldwide; however, the longevity of vaccine effectiveness is not known. Objective: We performed a prospective observational study to assess the antibody response of healthcare workers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after BNT162b2 mRNA COVID-19 vaccination. Methods: SARS-CoV-2 neutralizing antibody (nAb) and spike (S) protein-IgG (S-IgG) antibody titers were examined in participants who received two doses of the BNT162b2 mRNA COVID-19 vaccine in a single center between March 1, 2021, and October 11, 2021. Antibody levels were analyzed at four times: before vaccination (visit 1), 4 weeks after the first vaccination (visit 2), 3 months after the second vaccination (visit 3), and 6 months after the second vaccination (visit 4). Results: A total of 249 healthcare workers at Jeju National University Hospital were enrolled in this study, and 982 blood samples were an ....

Ha Afon , Jeju Island , Cheju Do , South Korea , United States , South Africa , Republic Of Korea , Moreira Ed Jr , Johnson Janssen , Abbot Korea Ltd , Jeju National University Hospital , Large Integrated Health System , Prevention Agency , Department Of Laboratory Medicine , Vaccine Among Us Health Care Personnel , Departments Of Laboratory Medicine , Abbott Ireland Diagnostics Division , Institutional Review Board , Laboratory Medicine , Korean Peninsula , Fully Vaccinated , Supplementary Figure , Korea Disease Control , Abbot Korea , Supplementary Material , Retrospective Cohort ,

Frontiers | HLA Does Not Impact on Short-Medium-Term Antibody Response to Preventive Anti-SARS-Cov-2 Vaccine

Frontiers | HLA Does Not Impact on Short-Medium-Term Antibody Response to Preventive Anti-SARS-Cov-2 Vaccine
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Roche Cobas , Fondazione Pascale Cancer Center Naples , International Standards , Lambda Inc , National Cancer Institute Pascale , International Standard , Roche Elecsys , Binding Arbitrary Units , One Lambda Inc , Short Term Antibody , National Cancer Institute , Between Ab Titer , Long Persisting , Short Persisting , Institutional Ethical Committee , Istituto Nazionale Tumori , Campania Region , From Basic Principles , Nat Rev Immunol , Med Abstract , Crossref Full Text , Ncov Epidemic Threat , Novel Coronaviruses , Global Health , Coronavirus Outbreak , Inf Dis ,

Frontiers | Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients


2Luebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany
3General Surgery Department, Tawam Hospital, SEHA, Al Ain, United Arab Emirates
4Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
5Department of Genetics and Molecular Biology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates
6Department of Respiratory Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates
7Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada
8Division of Surgery and Interventional Science, University College London, London, United Kingdom
As one of the current global health conundrums, COVID-19 pandemic caused a dramatic increase of cases exceeding 79 million and 1.7 million deaths worldwide. Severe presentation of COVID-19 is characterized by cytokine storm and chronic inflammation resulting in multi-organ dysfunction. Curre ....

South Korea , Ash Shariqah , United Arab Emirates , Abu Dhabi , Abuz Aby , Gholamrezanezhada Extrapulmonary , Clin Chim Acta , Acta Haematologica , Cortijoj Mucins , Argininosuccinate Synthetase , Minghimr Interactivenn , Albrechtm Altanalyze , Fitzeg Hsp , Deutsche Forschungsgemeinschaft , Lysophosphatidylcholine Acyltransferase , J Physiol Endocrinol , Abu Dhabi Health , Research Ethics , Research Ethics Committee , Nuclear Receptors , German Research Foundation Under Germany Excellence Strategy , World Health Organization , Sharjah Research Academy Grant , University Of Sharjah , Their Association With Disease Outcomes In Severe , Dubai Scientific Research Ethics Committee ,

Covid variants story can't be used to keep us oppressed

Covid variants story can't be used to keep us oppressed
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United States , United Kingdom , Jasona Greenbaum , Emilya Teslow , Edwardc Holmes , Julianes Walz , Ellen Shrock , Mehuls Suthar , N Le Bert , Swapnil Mahajan , John Pa Ioannidis , Yale University , British Society For Immunology , Advisory Committee On Immunization Practices , University Hospital , Global Initiative On Sharing Avian Influenza Data , Jolla Institute For Immunology , Global Initiative , Sharing Avian Influenza , Molecular Basis , Molecular Cell , Nature Microbiology , British Society , Antibody Response , Medical Affairs , Nat Rev Immunol ,