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Ultrasound Ablation for PD: Benefit Limited by Adverse Effects

Parkinson's Motor Function Improved with Focused Ultrasound


Dec 29, 2020
But adverse events were frequent and persistent, trial shows
Focused ultrasound subthalamotomy improved motor function in Parkinson’s disease, but it also led to multiple adverse events that persisted in some patients, a small randomized double-blind trial found.
“Focused ultrasound subthalamotomy in one hemisphere improved motor features of Parkinson’s disease in selected patients with asymmetric signs,” wrote Raul Martinez-Fernandez, MD, PhD, of CEU San Pablo University in Mostoles, Spain, and co-authors in
. “Adverse events included speech and gait disturbances, weakness on the treated side, and dyskinesia.”
Patients with asymmetric Parkinson’s disease who had motor signs not fully controlled with medication and who were not candidates for deep-brain stimulation surgery were randomized to focused ultrasound subthalamotomy on the side opposite their main motor signs (n=27) or a sham procedure (n=13). ....

United States , Paul Smyth , Raul Martinez Fernandez , Joel Perlmutter , San Pablo University In Mostoles , Movement Disorder Society , Ultrasound Foundation , Boston Scientific , Washington University In St , University Of Virginia Center , Pablo University , New England Journal , Unified Parkinson , Disease Rating Scale , Mwiza Ushe , Washington University , Patient Global Impression , Contributing Writer , Focused Ultrasound Foundation , Hospitales De Madrid , Virginia Center , ஒன்றுபட்டது மாநிலங்களில் , பால் ஸ்மித் , ரால் மார்டினெஸ் பெர்னாண்டஸ் , ஜோயல் பேர்ல்முத்தேர் , இயக்கம் கோளாறு சமூகம் ,

Parkinson's Motor Symptoms Improve With Focused Ultrasound


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Focused ultrasound in one brain hemisphere improved motor function on the opposite side of the body in people with Parkinson s disease, but led to frequent, persistent adverse events, a small sham-controlled trial showed.
In a select group of patients with markedly asymmetric Parkinson s signs, focused ultrasound subthalamotomy led to a significant improvement in Movement Disorder Society-Unified Parkinson s Disease Rating Scale motor scores (MDS-UPDRS III) at 4 months compared with sham treatment, with a between-group difference of 8.1 points (95% CI 6.0-10.3,
P ....

Judy George , Joel Perlmutter , Movement Disorder Society , Washington University In St , Movement Disorder Society Unified Parkinson , Disease Rating Scale , England Journal , Mwiza Ushe , Washington University , Medpage Today , Englj Med , ஜூடி ஜார்ஜ் , ஜோயல் பேர்ல்முத்தேர் , இயக்கம் கோளாறு சமூகம் , வாஷிங்டன் பல்கலைக்கழகம் இல் ஸ்டம்ப் , இயக்கம் கோளாறு சமூகம் ஒருங்கிணைந்த பார்கின்சன் , நோய் ரேடிஂக் அளவு , இங்கிலாந்து இதழ் , வாஷிங்டன் பல்கலைக்கழகம் ,