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Functional Protein Measuring Technology Could Advance Drug Discovery |

A new biomedical research tool that enables scientists to measure hundreds of functional proteins in a single cell could offer new insights into cell machinery ....

Jun Wang , Liwei Yang , Renaissance School Of Medicine , Nature Communications , Stony Brook Cancer Center , Memorial Sloan Kettering Cancer Center Support Grant , Multiplex Biotechnology Laboratory , Associate Professor , Biomedical Engineering , Stony Brook University , Multiplex Biotechnology , Renaissance School , National Institutes , National Institute , Memorial Sloan Kettering Cancer Center Support , Cancer Center , College Of Engineering And Applied Sciences , College Of Engineering Amp Applied Sciences , School Of Medicine ,

New Functional Protein Measuring Technology Could Advance Drug Discovery Research |

STONY BROOK, NY, June 29, 2022 – A new biomedical research tool that enables scientists to measure hundreds of functional proteins in a single cell could offer new insights into cell machinery. Led by Jun Wang, Associate Professor of Biomedical Engineering at Stony Brook University, this microchip assay called the single-cell cyclic multiplex in situ tagging (CycMIST) technology – may help to advance fields such as molecular diagnostics and drug discovery. Details about the cyclic microchip assay method are published in Nature Communications. While newer technologies of single-cell omics (ie, genomics, transcriptomics, etc.) are revolutionizing the study of complex biological and cellular systems and scientists can analyze genome-wide sequences of individual cells, these technologies do not apply to proteins because they are not amplifiable like DNAs. Thus, protein analysis in single cells has not reached large-scale experimentation. Because proteins represent cell functions a ....

Jun Wang , Liwei Yang , Renaissance School Of Medicine , Nature Communications , Stony Brook Cancer Center , Memorial Sloan Kettering Cancer Center Support Grant , Multiplex Biotechnology Laboratory , Associate Professor , Biomedical Engineering , Stony Brook University , Multiplex Biotechnology , Renaissance School , National Institutes , National Institute , Memorial Sloan Kettering Cancer Center Support , Featured Press Story , Press Release ,