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New target identified for treatment of premature aging disease

Scientists discovered that a particular RNA accumulates in people with progeria, and that inhibiting the RNA reverses signs of aging and extends life span in mice. ....

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New target identified for treatment of premature aging disease

New target identified for treatment of premature aging disease
scienceblog.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from scienceblog.com Daily Mail and Mail on Sunday newspapers.

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Salk researchers discover how RNA processing goes awry in rare immune disease - Salk Institute for Biological Studies

Salk researchers discover how RNA processing goes awry in rare immune disease - Salk Institute for Biological Studies
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Saudi Arabia , Xuan Zhou , Jing Qu , Mo Li , Reyna Hernandez Benitez , Muhammad Tehseen , Jinsong Qiu , Izpisua Belmonte , Patrizia Comoli , Samir Hamdan , Changwei Shao , Concepcion Rodriguez Esteban , Jamesj Moresco , Sarah Dunn , Francesco Frassoni , Gerardo Ramos Mandujano , Manalm Andijani , Jinna Xu , Zhongwei Li , Yuta Takahashi , Xiang Dong Fu , Young Kim , Keiichiro Suzuki , Christopher Benner , Tomoaki Hishida , Maxim Shokhirev ,

New study shows how to boost muscle regeneration and rebuild tissue

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IMAGE: Induction of Yamanaka factors (OKSM) in muscle fibers increases the number of myogenic progenitors. Top, control; bottom, treatment. Red-pink color is Pax7, a muscle stem-cell marker. Blue indicates muscle nuclei..
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Credit: Salk Institute
LA JOLLA (May 25, 2021) One of the many effects of aging is loss of muscle mass, which contributes to disability in older people. To counter this loss, scientists at the Salk Institute are studying ways to accelerate the regeneration of muscle tissue, using a combination of molecular compounds that are commonly used in stem-cell research.
In a study published on May 25, 2021, in
Nature Communications, the investigators showed that using these compounds increased the regeneration of muscle cells in mice by activating the precursors of muscle cells, called myogenic progenitors. Although more work is needed before this approach can be applied in humans, the research provides insight into t ....

Izpisua Belmonte , Hsin Kai Liao , Fundacion Ramon Areces , Futbolistas Espanoles , Tomoaki Hishida , Estrella Nunez Delicado , Pradeep Reddy , Ruben Rabadan Ros , Paloma Martinez Redondo , Concepcion Rodriguez Esteban , Isabel Guillen , Zaijun Ma , Pedro Guillen Garcia , Fundacion Pedro Guillen , Juan Carlos Izpisua Belmonte , Chao Wang , Roger Guillemin , Nature Communications , Salk Institute , Moxie Foundation , Salk Professor Juan Carlos Izpisua Belmonte , Roger Guillemin Chair , Lei Shi , Yuan Xue , Ling Huang , Universidad Catolica San Antonio De Murcia ,

Researchers generate human-monkey chimeric embryos

Credit: Weizhi Ji, Kunming University of Science and Technology
Investigators in China and the United States have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease. The work appears April 15 in the journal
Cell.
As we are unable to conduct certain types of experiments in humans, it is essential that we have better models to more accurately study and understand human biology and disease, says senior author Juan Carlos Izpisua Belmonte, a professor in the Gene Expression Laboratory at the Salk Institute for Biological Sciences. An important goal of experimental biology is the development of model systems that allow for the study of human diseases under in vivo conditions. ....

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