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New molecular driver of frontal circuit maturation discovered


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IMAGE: Hirofumi Morishita, MD, PhD, Associate Professor of Psychiatry, Neuroscience and Opthalmology at the Icahn School of Medicine at Mount Sinai and lead author of the study.
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Credit: Mount Sinai Health System
Mount Sinai Researchers find a new way to prevent attention deficits associated with Fragile X, a leading genetic cause of autism, in an animal model
Corresponding Author: Hirofumi Morishita, MD, PhD, Department of Psychiatry, Neuroscience, Friedman Brain Institute, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York.
Bottom Line: The adolescent maturation of the frontal cortex is important for establishing cognitive function, and disruption of this process is associated with neurodevelopmental disorders. This study uncovered a new molecular driver of frontal circuit maturation that is essential for cognitive function, and demonstrated, in an animal model, that this mechanis ....

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