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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions. Inside the cell nucleus, anchoring to nucleosomes and competition with chromatin architectural proteins jointly prohibit cGAS activation by genomic DNA8–15. However, the fate of nuclear cGAS and its role in cell physiology remains unclear. Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING ubiquitin ligase 5 (CRL5) complex to ligate ubiquitin onto nuclear cGAS. A cryo-electron microscopy structure of nucleosome-bound cGAS in a complex ....

Cytiva Akt , Lipofectamine Rnai , Jackson Immunoresearch , Microplates Perkin Elmer , Q Exactive Orbitrap , Phenoplate Perkinelmer , Proteome Software , Cell Signaling Technology , Electron Microscopy Sciences , Image Lab Software , Ge Healthcare Life Sciences , Carl Zeiss , Cell Biologics , Thermo Fisher Scientific , Supplementary Table , Thermo Fisher , Select Human Ubiquitin , Life Sciences , Perkin Elmer , Life Technologies , Omplete Protease Inhibitor Cocktail , Alexa Fluor , Santa Cruz , Click It Edu Imaging Kit , Mini Kit , Trans Blot Turbo ,

Shark Tank India Season 3 Episode 21: What Is Chefling?

Shark Tank India season 3 recently witnessed the Chefling, who offer a unique DIY kit for the cooking enthusiast. Here are the full details. ....

Rounit Kashyap Gambhir , Shark Tank India , Mini Kit , Chefling Purchase , Tank India ,

QIAGEN earns ACT Label for new eco-friendlier QIAwave products and achieves first My Green Lab Platinum certification

QIAGEN earns ACT Label for new eco-friendlier QIAwave products and achieves first My Green Lab Platinum certification
tmcnet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from tmcnet.com Daily Mail and Mail on Sunday newspapers.

Phoebe Loh , Thomas Theuringer , Daniela Berheide , John Gilardi , My Green Lab , Exchange Commission , Life Sciences , Us Securities Exchange , My Green Lab Platinum , Green Lab Platinum , Frankfurt Prime Standard , Green Lab , Impact Factor Label , Mini Kit , Environmental Impact Factor , Nitin Sood , Senior Vice President , Science Based Targets , Molecular Diagnostics , Exchange Act , Annual Report ,

QIAGEN earns ACT Label for new eco-friendlier QIAwave products and achieves first My Green Lab Platinum certification

Venlo, the Netherlands, Feb. 15, 2024 (GLOBE NEWSWIRE) QIAGEN (NYSE: QGEN; Frankfurt Prime Standard: QIA) today announced two significant ach. ....

Us Securities Exchange , Life Sciences , My Green Lab , Exchange Commission , Frankfurt Prime Standard , Green Lab , Impact Factor Label , Mini Kit , Environmental Impact Factor , Nitin Sood , Senior Vice President , Science Based Targets , Molecular Diagnostics , Exchange Act , Annual Report ,

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , South Korea , Dimethylacetamide Dmac , Nanozoomer Hamamatsu , Kaplan Meier , Ut Southwestern Medical Center , Q Zhong Ut Southwestern Medical Center , Yj Oh Yonsei University , Signalstain Antibody Diluent Cell Signaling Technology , Talazoparib Pfizer Inc , Signalstain Citrate Unmasking Solution Cell Signaling Technology , Ut Southwestern Medical Center Genomics Core , Biosplice Inc , A Kung Dana Farber Cancer Institute , Jackson Laboratory , Proteome Discoverer Software Thermo Fisher Scientific , Therapeutic Oncology Research , Hamon Center , Proteomexchange Consortium , D Baltimore California Institute Of Technology , Drug Administration , Cell Signaling Technology , Tandem Mass Tag , Gene Ontology , Cancer Dependency Map , Drug Sensitivity ,