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Small ring insertion expands structural editing toolbox

Small ring insertion expands structural editing toolbox
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United States , Los Angeles , Kendall Houk , Mingji Dai , Frank Glorius , Richmond Sarpong , Emory University , University Of California ,

'Undruggable' cancer protein becomes druggable, thanks to shrub


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IMAGE: Mingji Dai, professor of chemistry and a scientist at the Purdue University Center for Cancer Research, studied the compound found naturally in the roots of a shrub and discovered a.
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Credit: Purdue University photo/Charles Jischke
A chemist from Purdue University has found a way to synthesize a compound to fight a previously undruggable cancer protein with benefits across a myriad of cancer types.
Inspired by a rare compound found in a shrub native to North America, Mingji Dai, professor of chemistry and a scientist at the Purdue University Center for Cancer Research, studied the compound and discovered a cost-effective and efficient way to synthesize it in the lab. The compound curcusone D has the potential to help combat a protein found in many cancers, including some forms of breast, brain, colorectal, prostate, lung and liver cancers, among others. The protein, dubbed BRAT1, had previously been deemed undruggable ....

United States , Mingji Dai , Alexander Adibekian , Purdue University , Scripps Research Institute , National Institutes Of Health , Drug Administration , Purdue University Center , National Science Foundation , Cancer Research , A National Cancer , North America , National Institutes , National Science , National Cancer Institute Designated , ஒன்றுபட்டது மாநிலங்களில் , பர்‌ட்யூ பல்கலைக்கழகம் , ஸ்கிரிப்ட்கள் ஆராய்ச்சி நிறுவனம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , பர்‌ட்யூ பல்கலைக்கழகம் மையம் , தேசிய அறிவியல் அடித்தளம் , புற்றுநோய் ஆராய்ச்சி , வடக்கு அமெரிக்கா , தேசிய நிறுவனங்கள் , தேசிய அறிவியல் , தேசிய புற்றுநோய் நிறுவனம் நியமிக்கப்பட்ட ,