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The film is a fictionalized account of the 1947 smallpox outbreak in New York City and the systematic, citywide vaccination program in April of that year that brought the immense danger to an end.

New yorkUnited statesLower east sideFrance generalAmerican museum of natural historyCity ofUnited kingdomNew yorkerHarry essexCharles vidor gildaRobert floreyHansj salterRobert aldrichRochelle walenskySheila bennet evelyn keyesLudwig donath