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MicroRNA may serve as therapeutic targets for traumatic brain injury


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Scientists at the Walter Reed Army Institute for Research have shown that microRNA biomarkers related to Alzheimer s disease play a role in brain damage caused by traumatic brain injury.
TBI or brain trauma results from blows to the head, leading to chronic disruption of the brain and a cascade of long-term health conditions. Patients who suffer from TBI are at much higher risk of developing neurodegenerative disease or dementia, particularly Alzheimer s disease. The mechanism behind this relationship remains understudied, making the development effective therapeutics challenging.
MiRNAs are small pieces of genetic material that play a critical role in normal gene expression. Yet, studies have also linked abnormal miRNA levels, or dysregulation, to a range of diseases including neurodegenerative disorders and cell death after TBI, making them a subject of great interest to researchers who hope to use them as biomarkers and novel targets of drug therapies. ....

Bernards Wilfred , Bharani Thangavelu , Angelam Boutte , Brain Trauma Neuroprotection Branch , Walter Reed Army Institute For Research , Walter Reed Army Institute , Military Psychiatry , Molecular Biology , Medicine Health , Alzheimers Disease , பெர்னார்டுகள் வில்ஃப்ரெட் , பரணி தங்கவேலு , வால்டர் நாணல் இராணுவம் நிறுவனம் க்கு ஆராய்ச்சி , வால்டர் நாணல் இராணுவம் நிறுவனம் , இராணுவம் மனநல மருத்துவம் , மூலக்கூறு உயிரியல் , மருந்து ஆரோக்கியம் , அல்சைமர் நோய் ,