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Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages. ....

Higher Education , Lung Cancer , Non Small Cell Lung Cancer , Small Cell Lung Cancer , Growth Factor , Pd L1 ,

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Researchers evaluated rational combination treatment regimens for advanced/metastatic non-small-cell lung cancer (NSCLC). ....

Sewcreamstudio Shutterstock , Nature Medicine , Ene Expression , Lung Cancer , Monoclonal Antibody ,

CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient. ....

San Francisco , United States , Trinidad And Tobago , Cindy Sandoval Espinoza , Jennifer Doudna , Hyung Kang , Barbara Perez , Evelyn Chen , Wayne Ngo , University Of California , National Institute , Innovative Genomics Institute , Us Department Of Energy , Howard Hughes Medical Institute , Uc Berkeley Department Of Molecular , National Institutes Of Health , Nature Biotechnology , Jennifer Hamilton , Enterprising Science , Min Hyung Kang , Marena Trinidad , Cell Biology , Gladstone Institutes , National Institutes , Emerson Collective , Howard Hughes Medical ,

Is there an association between vitamin D, immunocompetence, and aging?

The role of an individual’s immunocompetence in the responsiveness to vitamin D. ....

Central Role , Image Credit , Vitamin D , One Health , Immune System , Progenitor Cells , Vitamind Deficiency ,

Revolutionary RNA-based switch offers new control over gene expression in mammalian cells

Researchers developed an RNA-based switch, the pA regulator system, to control gene expression in mammalian cells by modulating synthetic polyA signal cleavage, offering a novel approach for gene therapy applications. ....

United States , Drug Administration , Nature Biotechnology , United States Food , Flow Cytometry , Ene Expression , Gene Therapy , Gene Transfer , N Vivo , Mammalian Cells , Polymerase Chain Reaction , Ibonucleic Acid , Rna Extraction ,