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Redefining quality in cell line development: Advanced tech

From monoclonality to droplet-based technology, find out the key to cell line development success ....

Richard Hammond , European Medicines Agency , Drug Administration , Editorial Article , Chief Technical Officer , Sphere Fluidics , Chief Technology Officer , Sphere Fluidic , Redefining Quality In Cell Line Development The Power Of Advanced Technologies Selectscience , Roplet Based Technology , Drug Development , Antibody Therapeutics , Workflow Automation ,

New method could revolutionize the delivery of antioxidants to stem cells

As we age, our bodies change and degenerate over time in a process called senescence. Stem cells, which have the unique ability to change into other cell types, also experience senescence, which presents an issue when trying to maintain cell cultures for therapeutic use. ....

Hee Sun Han , Ryan Miller , Lily Ramsey , Hyunjoon Kong , Stem Cells , Mesenchymal Stem Cells ,

U.S. patent granted for novel tool designed to reliably diagnose and monitor sickle cell disease

In the United States, sickle cell disease affects about 100,000 people and about 2 million Americans carry this genetic mutation. ....

United States , Megan Craig , Stella Batalama , College Of Engineering , Florida Atlantic University Department Of Ocean , Trademark Office , Florida Atlantic University , Mechanical Engineering , Computer Science , United States Patent , Sickle Cell Disease , Blood Disorder , Blood Vessels , Flow Cytometry , Life Expectancy , Red Blood Cells ,

Transforming antibiotic resistance testing: a novel, rapid and affordable technique

News Medical speaks with Dr. Sandor Kasas, a lead researcher at Ecole Polytechnique Fédérale de Lausanne in Switzerland. ....

Ronnie Willaert , Sandor Kasas , Ecole Polytechnique , Lily Ramsey , Sandor Kasasresearch Leadecole Polytechnique , Irinaa Chelnokova , Fahroni Shutterstock , Research Foundation Flanders , European Space Agency , Swiss National Science Foundation , University Of Fribourg , Optical Nanomotion Detection , Vrije Universiteit Brussel , Cell Optical Nanomotion , Rapid Antifungal Susceptibility , Horii Huber , Single Cell Nanomotion Behaviour , Microfluidic Chip , Antibiotic Resistance , Antimicrobial Resistance , Atomic Force Microscopy , Candida Albicans , Cell Wall , Global Health ,

"Considerations for modelling diffuse high-grade gliomas and developing" by Sarah L. Higginbottom, Eva Tomaskovic-Crook et al.

Diffuse high-gradegliomas contain some of the most dangerous human cancers that lack curative treatment options. The recent molecular stratification of gliomas by the World Health Organisation in 2021 is expected to improve outcomes for patients in neuro-oncology through the development of treatments targeted to specific tumour types. Despite this promise, research is hindered by the lack of preclinical modelling platforms capable of recapitulating the heterogeneity and cellular phenotypes of tumours residing in their native human brain microenvironment. The microenvironment provides cues to subsets of glioma cells that influence proliferation, survival, and gene expression, thus altering susceptibility to therapeutic intervention. As such, conventional in vitro cellular models poorly reflect the varied responses to chemotherapy and radiotherapy seen in these diverse cellular states that differ in transcriptional profile and differentiation status. In an effort to improve the relevance ....

World Health Organisation , 3d Printing , Clinically Relevant , Lioma Stem Cells , High Grade Glioma , Preclinical Models , Tissue Engineering , Tumour Microenvironment ,