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Precise activation and tracking of cancer treatment with a new compound is possible

This class of inhibitors has shown therapeutic promise in several cancer types, including chronic lymphocytic leukemia and Burkitt lymphoma

United statesDylan hortonKimberlee speakmanWistar instituteUniversity of south floridaMicroenvironment metastasis programSouth floridaMetastasis programEnhanced anticancer compound may allowPrecise activationGood morning america

Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

Lily ramseyQing chenRonald caplan cancer centerWistar instituteNature communicationsMicroenvironment metastasis programImage creditMetastasis programBrain metastasesBrain cellBreast cancer

Study gives new insight into how cancer metastasizes to the brain

Study gives new insight into how cancer metastasizes to the brain
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Weili maQing chenNature communicationsNational cancer instituteWistar instituteRonald caplan cancer centerMicroenvironment metastasis programIngenuity pathwayMetastasis program

Wistar scientists reveal a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular senescence

Aging and age-related disorders pose a complex challenge to the biomedical research community. To better understand how senescence is regulated is of high significance to promote healthy aging and treat age-associated disorders.

Rugang zhangChristopherm davisXue haoKazuko nishikuraEmily hendersonGene expression regulation program at wistar ellenRonald caplan cancer centerMicroenvironment metastasis programWistar instituteNature cell biologyEndowed professorMetastasis programGene expressionRegulation programCell biology

Wistar scientists discover a new way to boost a person s immune response to tumors

Due to the development of resistance to chemotherapy and recurring tumors, patients with ovarian cancer often have low survival rates.

Rugang zhangSergey karakashevEmily hendersonCancer immunology researchRonald caplan cancer centerMicroenvironment metastasis programWistar instituteMetastasis programImmune responseCancer treatmentImmune systemN vitroN vivoOvarian cancer