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"Predicting the Biological Effects of Human Salivary Gland Tumour Cells" by Sung Hyun Lee, Kota Mizushima et al.

Experimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland tumour (HSGc‐C5) cells, microdosimetric quantities measured by a silicon‐on‐insulator (SOI) MicroPlus‐mushroom microdosimeter along the spread‐out Bragg peak (SOBP) delivered by pencil beam scanning of4He,12C,16O, and 20 Ne ions were used. The MK model parameters of HSGc‐C5 cells were obtained from the best fit of the calculated SF for the different linear energy transfer (LET) of these ions and the formerly reported in vitro SF for the same LET and ions used for calculations. For a cube‐shaped target of 10 × 10 × 6 cm3, treatment plans for4He,12C,16O, and20Ne ions were produced with proprietary treatment planning software (TPS) aiming for 10% SF of HSGc‐C5 cells over the target volume and were delivered to a polymeth ....

Microdosimetric Kinetic Model , Ulti Ion Therapy , Relative Biological Effectiveness , Silicon On Insulator ,

"In-field and out-of-field microdosimetric characterisation of a 62 MeV" by Benjamin James, Linh T. Tran et al.

"In-field and out-of-field microdosimetric characterisation of a 62 MeV" by Benjamin James, Linh T. Tran et al.
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Friuli Venezia Giulia , Adroterapia Applicazioni Nucleari Avanzate , University Of Wollongong , Centre For Medical Radiation Physics , Medical Radiation Physics , Microdosimetric Kinetic Model , ப்ர்ிஉலி வெனீசியா கியுலியா , பல்கலைக்கழகம் ஆஃப் வாலாஂகஂக் , மையம் க்கு மருத்துவ கதிர்வீச்சு இயற்பியல் , மருத்துவ கதிர்வீச்சு இயற்பியல் ,

"Estimating the biological effects of helium, carbon, oxygen, and neon " by Sung Hyun Lee, Kota Mizushima et al.

Abstract
In this study, the survival fraction (SF) and relative biological effectiveness (RBE) of pancreatic cancer cells exposed to spread-out Bragg peak helium, carbon, oxygen, and neon ion beams are estimated from the measured microdosimetric spectra using a microdosimeter and the application of the microdosimetric kinetic (MK) model. To measure the microdosimetric spectra, a 3D mushroom silicon-on-insulator microdosimeter connected to low noise readout electronics (MicroPlus probe) was used. The parameters of the MK model were determined for pancreatic cancer cells such that the calculated SFs reproduced previously reported in vitro SF data. For a cuboid target of 10 × 10 × 6 cm3, treatment plans of helium, carbon, oxygen, and neon ion beams were designed using in-house treatment planning software (TPS) to achieve a 10% SF of pancreatic cancer cells throughout the target. The physical doses and microdosimetric spectra of the planned fields were measured at different dept ....

Microdosimetric Kinetic Model , Ulti Ion Therapy , Relative Biological Effectiveness , Urvival Fraction ,