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Investegate |MeiraGTx Announcements | MeiraGTx: MeiraGTx Announces Data at EURETINA 2021 Virtual Meeting Demonstrating Reversal of Disease Progression Following Treatment with AAV5-RPGR in X-Linked Retinitis Pigmentosa

Investegate |MeiraGTx Announcements | MeiraGTx: MeiraGTx Announces Data at EURETINA 2021 Virtual Meeting Demonstrating Reversal of Disease Progression Following Treatment with AAV5-RPGR in X-Linked Retinitis Pigmentosa
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Partial sight restored for man who is blind thanks to optogenetics

Sahel et al, Nature Medicine and StreetLab/Institut de la Vision
A man who is blind has had glimmers of vision restored thanks to a high-tech treatment using optogenetics, which involves genetically altering nerve cells so they respond to light.
French firm GenSight Biologics has published results showing that the first recipient of its treatment can recognise different objects in lab tests. “It’s exciting to see the first publication on human optogenetics,” says Ed Boyden at the Massachusetts Institute of Technology in Boston, a co-inventor of optogenetics.
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Optogenetics has become a widely used lab tool, because it allows precision control over brain cells by altering them so they fire in response to light. It has led to many discoveries about the brain when used in animals – but is thought to have limited medical potential for treating brain disorders in people, because getting light inside the head requires implanting a fibre optic cable. ....

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Gene therapy injected in one eye improves vision in both

Gene therapy injected in one eye improves vision in both
Appeared in BioNews 1076
Vision improves in both eyes when gene therapy is administered to only one eye, an international team of researchers has found, whilst treating a rare form of blindness.
The team injected a harmless virus containing the gene into the back of one eye of 37 patients who had vision loss for six to 12 months from a condition called Leber hereditary optic neuropathy (LHON). Nearly two years after treatment, 29 of them had at least some vision improvements in both eyes. Of these, 25 had clinically relevant improvement in their treated eye. ....

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