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Alternative cellular 'fuels' boost immunity

A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study by Van Andel Institute scientists and collaborators. The findings, published today in Immunity, may pave the way for future personalized dietary recommendations to augment treatments for infection, cancer and other diseases. ....

Grand Rapids , United States , Bradleym Dickson , Danielp Kelly , Shelby Compton , Joseph Longo , Scottb Rothbart , Van Andel , Peter Crawford , Ryand Sheldon , Zachary Madaj , Irem Kaymak , Kelseys Williams , Ariana Kupai , Conniem Krawczyk , Laurenr Duimstra , Erich Ma , Michaels Dahabieh , Michel Boisvert , Patrycja Puchalska , Russell Jones , Brandonm Oswald , Zhen Fu , Vice Dean For Research , National Institutes Of Health , University Of Pennsylvania ,

New RNA-seq, metabolomics protocol offers mor

Van Andel Institute scientists have developed a new extraction protocol for RNA-seq and metabolomic analysis, offering a more complete picture of cellular activity than either technique on its own. The protocol employs a streamlined extraction from a single sample, which reduces variation, improves efficiency, preserves data fidelity and maximizes use of precious biospecimens. ....

United States , Grand Rapids , Zacharyb Madaj , Christine Isaguirre , Marie Adams , Russellg Jones , Vijayvardhan Kamalumpundi , Scotta Givan , Michaels Dahabieh , Rebeccaa Siwicki , Van Andel , Marthal Escobar Galvis , Abigaile Ellis , Brejnev Muhire , Bryan Sheldon , Institute Mass Spectrometry Core , Method Of Research , Department Of Metabolism , Van Andel Institute , Score Technologies , Lisa Decamp , Mass Spectrometry Core , Biorepository Core , Biostatistics Core , Genomics Core , Mandel Institute ,

Efficient protocol maintains RNA-seq, metabolomics data integrity

Efficient protocol maintains RNA-seq, metabolomics data integrity
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Abigaile Ellis , Rebeccaa Siwicki , Marthal Escobar Galvis , Bryan Sheldon , Christine Isaguirre , Vijayvardhan Kamalumpundi , Brejnev Muhire , Michaels Dahabieh , Scotta Givan , Zacharyb Madaj , Marie Adams , Russellg Jones , Institute Mass Spectrometry Core , Van Andel Institute , Department Of Metabolism , Score Technologies , Lisa Decamp , Mass Spectrometry Core , Biorepository Core , Biostatistics Core , Genomics Core , Van Andel ,