According to Port Orange police, the crash occurred at 7:22 p.m. on Sunday at the intersection of Nova Road and Sleepy Hollow Drive.
A passenger riding with Ferguson, identified as Nadine Smith of Ohio, was also taken to Halifax Health Medical Center and remains in stable condition, police said.
The driver of the vehicle was not injured, police said.
Port Orange police are asking anyone with information on the crash to call Port Orange Traffic Homicide Investigator Michael Garay at 386-506-5838.
Ferguson is the second motorcycle fatality that Port Orange worked during Bike Week.
On Wednesday, a 33-year-old Port Orange motorcyclist died when his motorcycle crashed at Country Lane and Taylor Road, police said.
Police: Bicyclist dies after being struck by vehicle in Port Orange orlandosentinel.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from orlandosentinel.com Daily Mail and Mail on Sunday newspapers.