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Furin cleavage site crucial in SARS-CoV-2 for viral transmission in ferrets, finds study

Furin cleavage site crucial in SARS-CoV-2 for viral transmission in ferrets, finds study
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global problem. Like other coronaviruses, SARS-CoV-2 utilizes its spike glycoprotein to gain access to host cells. The spike protein of SARS-CoV-2 becomes cleaved by cathepsin – a serine protease – for membrane fusion to occur between the virus and cell. However, due to it containing a polybasic cleavage site (CS), it can also be cleaved by furin-like enzymes expressed by the host cell.
Deleterious mutations occurring at the CS have been frequently documented in Vero cells, a popular laboratory cell line for testing replication of SARS-CoV-2. These mutations have been observed to reduce the polybasic nature of the site, potentially affecting the virus’ ability to gain cell entry. ....

United Kingdom , City Of , Michael Burgess , Michael Burgessapr , Imperial College London , ஒன்றுபட்டது கிஂக்டம் , நகரம் ஆஃப் , மைக்கேல் பர்கஸ் , ஏகாதிபத்தியம் கல்லூரி லண்டன் ,

Use of ozone as a decontaminant for SARS-CoV-2

Use of ozone as a decontaminant for SARS-CoV-2
Researchers in Germany have demonstrated how an ozone-based decontamination device significantly reduces the volume of viral residue left on surfaces of two surrogate viruses for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
The article is available to read in full on the
Ozone
Ozone is a volatile and unstable molecule comprised of three oxygen atoms found in trace amounts naturally in the Earth’s atmosphere. Due to its reactive tendencies, it has been found to highly effective in killing viruses, bacteria, fungi, and other pathogens.
As the COVID-19 pandemic continues, caused by SARS-CoV-2, the need for appropriate sterilization of hospitals and medicinal equipment is increasing. ....

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Could Zebrafish larvae be a novel animal model for SARS-CoV-2?

Researchers based in Paris, France, have explored the potential use of zebrafish larvae as animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These larvae are small and cheap, so could prove a suitable medium for rapid mass testing of the disease. ....

France General , Valerio Laghi , Michael Burgess , Jean Pierre Levraud , Michael Burgessapr , Pasteur Institute , Animal Model , Sars Cov 2 , Angiotensin Converting Enzyme 2 , Corona Virus , Coronavirus Disease Covid 19 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , பிரான்ஸ் ஜநரல் , மைக்கேல் பர்கஸ் , பாஸ்டர் நிறுவனம் , விலங்கு மாதிரி , கொரோனா வைரஸ் , சர்வதேச பரவல் , கடுமையானது எடுப்போசை சுவாச , கடுமையானது எடுப்போசை சுவாச நோய்க்குறி ,

Could cow's milk provide some passive immunity against COVID-19?

Could cow's milk provide some passive immunity against COVID-19?
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

Michael Burgess , Alena Demidyuk Shutterstock , Michael Burgessapr , Department Of Animal Health , University Of Cordoba , Animal Health , Bovine Coronavirus Immune Milk Against , Alena Demidyuk , மைக்கேல் பர்கஸ் , துறை ஆஃப் விலங்கு ஆரோக்கியம் , பல்கலைக்கழகம் ஆஃப் கார்டோபா , விலங்கு ஆரோக்கியம் ,

Researchers identify several novel SARS-CoV-2 inhibitors

Researchers identify several novel SARS-CoV-2 inhibitors
Researchers in London, UK, have identified several compounds with SARS-CoV-2 inhibiting properties, that potentially may be developed into antiviral solutions in the future.
A pre-print version of the research paper is available to read in full on the
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to circulate globally, despite the steady rollout of vaccines. More than 150,000 infectious cases are diagnosed daily across the world. Since the virus was first detected in December 2019, over 135 million cases of COVID-19 have been confirmed, with over 2.9 million deaths worldwide.
Most worrisome is the rapid appearance of multiple variants of concern (VOCs), many of which appear to have some degree of immunity to the vaccines. Thus, developing a novel antiviral compound that can target key sites of the virus to disable it is of great importance. The development of novel drug and vaccine t ....

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