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Melatonin could act as barrier against COVID-19 infection

Melatonin could act as barrier against COVID-19 infection
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Regina Pekelmann Markus , Melatonin Research , Professor Regina Pekelmann Markus ,

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2
Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, all of which are entry points for the virus.
The hormone, therefore, prevents infection of these cells by the virus and inhibits the immune response so that the virus remains in the respiratory tract for a few days, eventually leaving to find another host.
The discovery by researchers at the University of São Paulo (USP), in Brazil, helps understand why some people are not infected or do not manifest symptoms of COVID-19 even when reliably diagnosed as carriers of the virus by RT-PCR. In addition, it offers the prospect of nasal administration of melatonin, in drops or as a spray, to prevent disease from developing in pre-symptomatic patients. ....

Marcos Buckeridge , Helder Nakaya , Regina Pekelmann Markus , Emily Henderson , Melatonin Research , Institute Of Biosciences , Journal Of Pineal Research , School Of Pharmaceutical Sciences , Pekelmann Markus , Principal Investigator , Pineal Research , Pharmaceutical Sciences , Gene Expression , Immune Response , Sars Cov 2 , வைத்திருப்பவர் நாகாய , எமிலி ஹென்டர்சன் , நிறுவனம் ஆஃப் உயிர் அறிவியல் , பள்ளி ஆஃப் மருந்து அறிவியல் , ப்ரிந்ஸிபல் புலனாய்வாளர் , மருந்து அறிவியல் , கீந் வெளிப்பாடு , நோய் எதிர்ப்பு சக்தி பதில் , மன அழுத்தம் ,

Melatonin produced in lungs can prevent Covid-19 infection: Study

January 28, 2021
Melatonin encodes proteins in cells to prevent virus entry
Melatonin synthesised in the lungs acts as a barrier against Covid-19 infection. This also prevents the expression of genes that are entry points for the virus, researchers at the University of São Paulo (USP) stated in a study.
The study, published in the journal
Melatonin Research, found that melatonin encodes proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, to prevent virus entry.
The hormone, therefore, prevents infection of these cells by the virus and inhibits the immune response so that the virus remains in the respiratory tract for a few days. The virus eventually leaves to find another host. ....

Regina Pekelmann Markus , Melatonin Research , Institute Of Biosciences , Pekelmann Markus , நிறுவனம் ஆஃப் உயிர் அறிவியல் ,

Melatonin produced in the lungs prevents infection by novel coronavirus

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IMAGE: The hormone acts as a barrier against SARS-CoV-2, blocking the expression of genes that encode proteins in cells serving as viral entry points, according to a study by researchers at.
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Credit: NIAD/NIH
By Elton Alisson | Agência FAPESP - Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, all of which are entry points for the virus. The hormone, therefore, prevents infection of these cells by the virus and inhibits the immune response so that the virus remains in the respiratory tract for a few days, eventually leaving to find another host. ....

Elton Alisson , Marcos Buckeridge , Helder Nakaya , Regina Pekelmann Markus , Melatonin Research , Institute Of Biosciences , Journal Of Pineal Research , Paulo Research Foundation , School Of Pharmaceutical Sciences , Pekelmann Markus , Pineal Research , Pharmaceutical Sciences , எல்டன் அலிசன் , வைத்திருப்பவர் நாகாய , நிறுவனம் ஆஃப் உயிர் அறிவியல் , பாலொ ஆராய்ச்சி அடித்தளம் , பள்ளி ஆஃப் மருந்து அறிவியல் , மருந்து அறிவியல் ,