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Mouse pups' cries give clues about autism spectrum disorder


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IMAGE: Noboru Hiroi, PhD, and collaborators are studying which mouse pup cries are most predictive of the pups developing autism spectrum disorder later. Dr. Hiroi is a professor at The University.
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Credit: The University of Texas Health Science Center at San Antonio
SAN ANTONIO (May 27, 2021) One-fifth of babies who inherit a genetic variant located on chromosome 16 will develop autism spectrum disorder (ASD) by age 3. The variant is called 16p11.2 deletion.
Noboru Hiroi, PhD, of The University of Texas Health Science Center at San Antonio (also referred to as UT Health San Antonio), is studying mice that have this deletion. The team, which includes colleagues from Japan, Ireland and the U.S., is harnessing the power of machine learning to understand which vocalizations of the newborn mouse pups are most predictive of social abnormalities one month later when the pups reach puberty. ....

United States , University Hospital , Shinichi Tokuno , Richard Sharp , Cynthia Blanco , Itaru Kaneko , Amir Fayyazuddin , Mitsuteru Nakamura , Megumi Adachi , Katsunori Tajinda , Mitsuyuki Matsumoto , Takuma Mihara , Marka Geyer , Mariel Barbachane Silva , Masako Nagashima , Takeshi Hiramoto , Danielj Hoeppner , Shingo Enomoto , Takahira Yamauchi , Gina Kang , Emia Yuda , Noboru Hiroi , Albert Einstein College Of Medicine , National Institutes Of Health , Department Of Psychiatry , National Institute On Deafness ,