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New study throws light on mechanisms underlyi

Helicobacter pylori cagA+ strains cause gastric inflammation, ulcers, and cancer. Previous reports have shown that the cagA gene-encoded protein “CagA” plays a crucial role in gastric carcinogenesis. However, the underlying mechanisms remain to be fully elucidated. Researchers from Japan used animal models and laboratory-cultured human gastric epithelial cells to demonstrate that CagA works by disrupting the Wnt/Planar Cell Polarity (PCP) signaling pathway. ....

National University Of Singapore , Singapore General , Mengxue Lu , Christopher Takaya Knight , Takayoshi Yamamoto , Ippei Kikuchi , Atsushi Takahashi Kanemitsu , Etsuoa Susaki , Akira Kikuchi , Takuya Ooki , Nick Barker , Masanori Taira , Christophert Knight , Yusuke Mii , Masanori Hatakeyama , Takuo Hayashi , Department Of Molecular Biology , Akira Kikuchi Osaka University , Department Of Biological Sciences , Research Center , Takuo Hayashi Juntendo University , Ippei Kikuchi Institute Of Microbial Chemistry , Yong Loo Lin School Of Medicine , Laboratory Head , National Institute For Basic Biology , Laboratory Of Microbial Carcinogenesis ,

New study throws light on mechanisms underlying helicobacter pylori-induced gastric cancer

New study throws light on mechanisms underlying helicobacter pylori-induced gastric cancer
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National University Of Singapore , Singapore General , Takayoshi Yamamoto , Masanori Hatakeyama , Akira Kikuchi , Etsuoa Susaki , Takuo Hayashi , Nick Barker , Masanori Taira , Mengxue Lu , Takuya Ooki , Christopher Takaya Knight , Ippei Kikuchi , Atsushi Takahashi Kanemitsu , Christophert Knight , Yusuke Mii , Department Of Molecular Biology , Research Ci , Hokkaido University , Division Of Epithelial Stem Cell Biology , Laboratory Of Microbial Carcinogenesis , Yong Loo Lin School Of Medicine , Institute Of Microbial Chemistry , Technology Agency , Exploratory Research Center On Life , Masanori Hatakeyama Institute Of Microbial Chemistry ,

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. Clinical evidence suggests that infection with H. pylori cagA+ strains dramatically increases the risk of developing gastric cancer. ....

National University Of Singapore , Singapore General , Takayoshi Yamamoto , Mengxue Lu , Masanori Hatakeyama , Atsushi Takahashi Kanemitsu , Danielle Ellis , Nick Barker , Christophert Knight , Ippei Kikuchi Institute Of Microbial Chemistry , Takuya Ooki Institute Of Microbial Chemistry , Institute Of Microbial Chemistry , Kanazawa University , Yusuke Mii National Institute For Basic Biology , Juntendo University , Department Of Biochemistry Systems Biomedicine , Atsushi Takahashi Kanemitsu Juntendo University , Microbial Chemistry Research Foundation , Masanori Hatakeyama Institute Of Microbial Chemistry , Laboratory Head , Hokkaido University , Etsuoa Susaki Juntendo University , Akira Kikuchi Osaka University , University Of Tokyo , Masanori Taira Chuo University , Takuo Hayashi Juntendo University ,