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Patchwork of Mutations Contribute to Bipolar Disorder

Patchwork of Mutations Contribute to Bipolar Disorder
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Japan General , Atsushi Takata , Mizuho Ishiwata , Takashi Hayama , Shinichi Kuriyama , Masaki Nishioka , Kumiko Fujii , Jun Takayama , Tadafumi Kato , Junko Ueda , Toshiyuki Someya , Gen Tamiya , Naomi Sakai , Statistical Genetics Team , Department Of Psychiatry , Department Of Molecular Pathology Mood Disorders , Department Of Integrative Genomics , Research Institute For Diseases Of Old Age , Laboratory For Molecular Dynamics Of Mental Disorders , Juntendo University Graduate School Of Medicine , Tohoku University School Of Medicine , Juntendo University , Tohoku University , Laboratory For Molecular Pathology Of Psychiatric Disorders , Shiga University Of Medical Science , Tohoku Medical Megabank Organization ,

Research sheds new light on the genetic architecture of bipolar disorder

Bipolar disorder (BD) is a major psychiatric condition that afflicts about 1% of people. Symptoms of BD include sudden onset of depressive mood with loss of interest which alternates with a manic state of hyperactivity. ....

Masaki Nishioka , Atsushi Takata , Megan Craig , Tadafumi Kato , Juntendo University , Molecular Psychiatryon May , Associate Professor Masaki Nishioka , Bipolar Disorder , Exome Sequencing , Precision Medicine , Psychiatric Condition ,

Unraveling the Quirky Genetics of Bipolar Disorder

Bipolar disorder (BD) is a significant psychiatric condition that affects approximately 1% of the population. It is characterized by alternating episodes ....

Atsushi Takata , Tadafumi Kato , Masaki Nishioka , Juntendo University , Associate Professor Masaki Nishioka , Molecular Psychiatry , Brain Science ,

Patchwork of mutations contributing to bipola

Bipolar disorder (BD) is a serious psychiatric disorder affecting around 1% of the population worldwide. While medications are indispensable for these patients, they are not completely effective, and the underlying genetic architecture and pathogenesis of BD remain unresolved. Researchers from Japan have now used deep exome sequencing to show that mosaic variants/mutations found in genes related to developmental disorders and autism spectrum disease and in the mitochondrial tRNA region could be associated with BD. ....

Japan General , Jun Takayama , Tadafumi Kato , Gen Tamiya , Mizuho Ishiwata , Atsushi Takata , Takashi Hayama , Naomi Sakai , Junko Ueda , Masaki Nishioka , Toshiyuki Someya , Shinichi Kuriyama , Kumiko Fujii , Department Of Molecular Epidemiology , Tohoku University School Of Medicine , Laboratory For Molecular Pathology Of Psychiatric Disorders , Department Of Integrative Genomics , Department Of Psychiatry , Juntendo University , Laboratory For Molecular Dynamics Of Mental Disorders , Shiga University Of Medical Science , Method Of Research , Juntendo University Graduate School Of Medicine , Department Of Preventive Medicine , Statistical Genetics Team , Tohoku Medical Megabank Organization ,