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Effects of automation in the lives of longshoremen

This chapter in Stan Weir's Singlejack Solidarity tells the history of how, from the victory in the 1934 General Strike through the first Mechanization & Modernization (M&M) Agreement in 1961, longshore workers in San Francisco had 27 years of near-total control of the labor process on the waterfront in the "largest, longest, and most successful formal experiment in workers' control ever conducted in the United States." ....

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Mutation in a cancer-causing gene could exacerbate cerebral cavernous malformations in the brain

Mutation in a cancer-causing gene could exacerbate cerebral cavernous malformations in the brain
Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs) clusters of dilated blood vessels in the brain can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing anticancer drug showed promise in mouse models of CCMs in improving brain-vascular health and preventing bleeding into the brain tissue.
Previous studies linked the initial formation of CCMs to various environmental factors, including differences in the gut microbiome, and inactivating mutations in three specific genes collectively known as the CCM complex. While these changes are enough to cause small malformations to form in the brain, they didn t explain why some suddenly expand in size, resulting in seizures o ....

University Of Pennsylvania , United States , Markl Kahn , Emily Henderson , Perelman School Of Medicine , Perelman School , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , பெரல்மேன் பள்ளி ,

Cancer-linked mutation accelerates growth of abnormal stroke-causing brain blood vessels

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Researchers have discovered an explanation for why cerebral cavernous malformations (CCMs) clusters of dilated blood vessels in the brain can suddenly grow to cause seizures or stroke. Specifically, they found that a specific, acquired mutation in a cancer-causing gene (PIK3CA) could exacerbate existing CCMs in the brain. Furthermore, repurposing an already existing anticancer drug showed promise in mouse models of CCMs in improving brain-vascular health and preventing bleeding into the brain tissue.
Previous studies linked the initial formation of CCMs to various environmental factors, including differences in the gut microbiome, and inactivating mutations in three specific genes collectively known as the CCM complex. While these changes are enough to cause small malformations to form in the brain, they didn t explain why some suddenly expand in size, resulting in seizures or stroke. ....

University Of Pennsylvania , United States , Markl Kahn , Jim Koenig , Us Department Of Health , Human Services , National Institutes Of Health , Leducq Foundation , Perelman School Of Medicine , European Research Council , Blood Institute , National Heart , National Institute Of Neurological Disorders , Perelman School , National Institute , Neurological Disorders , Gallen Foundation , European Research , National Institutes , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , ஜிம் க்க்நிக் , எங்களுக்கு துறை ஆஃப் ஆரோக்கியம் , மனிதன் சேவைகள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , பெரல்மேன் பள்ளி ஆஃப் மருந்து ,

Cancer-linked mutation accelerates growth of abnormal stroke-causing brain blood vessels

Cancer-linked mutation accelerates growth of abnormal stroke-causing brain blood vessels
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University Of Pennsylvania , United States , Markl Kahn , Jim Koenig , European Research Council , Leducq Foundation , Blood Institute , National Heart , Perelman School Of Medicine , National Institute Of Neurological Disorders , Perelman School , National Institute , Neurological Disorders , Gallen Foundation , European Research , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , ஜிம் க்க்நிக் , ஐரோப்பிய ஆராய்ச்சி சபை , இரத்தம் நிறுவனம் , தேசிய இதயம் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , தேசிய நிறுவனம் ஆஃப் நரம்பியல் கோளாறுகள் , பெரல்மேன் பள்ளி , தேசிய நிறுவனம் , நரம்பியல் கோளாறுகள் ,