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Lead Exposure Can Lead to Epigenetic Changes In Brazil, automotive battery plants use lead to make their products, exposing workers to the element, which is abundant, natural, and highly toxic. In the United States, the use of lead was restricted in 1986. By American standards, lead poisoning occurs when a person s blood level of lead is above 40 micrograms per deciliter of blood (µg/dL). In Brazil, the law states that a level up to 60 μg/dl is acceptable; new research has called that into question. The work, which was reported in Frontiers in Genetics, has suggested that lead may have epigenetic impacts at even lower levels of exposure. ....
Workers with blood lead levels below the legal ceiling in Brazil expressed a microRNA associated with a decrease in DNA methylation, a physiological process required for the organism to be in balance. However, known clinical manifestations occur when levels are high. ....