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Original article published on august 30th 2021 in french. Do you know the word "senescence"? In biology, senescence is the physiological process that leads to the degradation of the cell's functions over time. In other words, senescence, from the Latin senex "old age", is the aging of organisms. From all times, scientists have sought to delay aging in an attempt to respect the Chinese proverb taken up by Malraux
Healthy cells can only divide a limited number of times during an organism's lifetime. In contrast, tumor cells are immortal: they proliferate indefinitely and uncontrollably, and this is the defining characteristic of cancer.
• Telomeres are the structures that protect the ends of chromosomes. The ability of tumor cells to continue dividing indefinitely, as if they were immortal, depends on telomeres
• When telomeres are damaged, lung cancer cells lose the ability to divide and the tumor shrinks, new results show
• Targeting telomeres aims at "taking immortality away from cancer cells," says Maria Blasco, senior author of the paper