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 E-Mail IMAGE: A dense-core amyloid-beta plaque (red) surrounded by microglia that lack TAM receptors (white) in the brain of a mouse with Alzheimer s disease view more  Credit: Salk Institute LA JOLLA (April 15, 2021) One of the characteristic hallmarks of Alzheimer s disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they ve largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful. The traditional view holds that the brain s trash-clearing immune cells, called microglia, inhibit the growth of plaques by eating them. The Salk scientists show instead that microglia promote the formation of dense-core plaques, and that this action sweeps wispy plaque material away from neurons, where it causes cell death. The research, which was published in

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