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Revealing HIV drug-resistance mechanisms through protein structures

Revealing HIV drug-resistance mechanisms through protein structures
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Zelin Shan , Stephenh Hughes , Nanjie Deng , Timothys Strutzenberg , Robert Craigie , Terrencer Burke Jr , Qinfang Sun , Stevenj Smith , Xue Zhi Zhao , Lorenzo Briganti , Avik Biswas , Mamuka Kvaratskhelia , Indrani Choudhuri , Allan Haldane , Dario Oliveira Passos , Dmitry Lyumkis , Zhaoyang Li , University Of Colorado Anschutz Medical Campus , Hearst Foundation Developmental Chair , Ronaldm Levy Of Temple University , Pace University , National Institute Of Diabetes , National Institutes Of Health , Science Advances , Salk Associate Professor Dmitry Lyumkis , Hearst Foundation Developmental ,

Salk researchers uncover molecular mechanisms of HIV drug resistance

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV. ....

Dmitry Lyumkis , Indrani Choudhuri , Allan Haldane , Avik Biswas , Stephenh Hughes , Mamuka Kvaratskhelia , Timothys Strutzenberg , Nanjie Deng , Dario Oliveira Passos , Robert Craigie , Megan Craig , Zhaoyang Li , Zelin Shan , Xue Zhi Zhao , Stevenj Smith , Terrencer Burke Jr , Qinfang Sun , Lorenzo Briganti , Salk Institute , National Institutes Of Health , University Of Colorado Anschutz Medical Campus , National Cancer Institute , Intramural Program , Margarett Morris Foundation , Intramural Targeted Program , Cancer Research ,

Revealing HIV drug-resistance mechanisms thro

Salk Institute researchers, in collaboration with the National Institutes of Health, have discovered the molecular mechanisms by which the human immunodeficiency virus (HIV) becomes resistant to Dolutegravir, one of the most effective, clinically used antiviral drugs for treating HIV. Their findings reveal how changes to the 3D structures of integrase, an HIV protein, can lead to Dolutegravir resistance and how other compounds may be able to overcome this resistance. ....

Lorenzo Briganti , Zhaoyang Li , Stephenh Hughes , Qinfang Sun , Zelin Shan , Allan Haldane , Robert Craigie , Dmitry Lyumkis , Indrani Choudhuri , Mamuka Kvaratskhelia , Stevenj Smith , Avik Biswas , Nanjie Deng , Terrencer Burke Jr , Timothys Strutzenberg , Dario Oliveira Passos , Xue Zhi Zhao , Intramural Program , Hearst Foundation , Hearst Foundation Developmental Chair , National Cancer Institute , University Of Colorado Anschutz Medical Campus , Salk Institute , National Institutes Of Health , Pace University , Cancer Research ,

Researchers Find Protein That Helps HIV-1 Navigate Through Cell

Proteins could become targets for long-acting therapies for patients suffering from AIDS-related illnesses
HIV-1, which causes AIDS, navigates a labyrinth of immune sensors and anti-viral attackers in order to reach a target-cell nucleus, where it permanently integrates into human DNA and spreads infection. How the virus traffics through this hostile environment has been a relative “black box” of mystery compared to other parts of the life cycle.
“We’re trying to understand the cellular proteins – which ones are helping this (HIV-1 core) structure travel all the way from the entry point to the nucleus, where HIV-1 permanently integrates into the human genome,” said Kvaratskhelia, a professor of medicine. ....

United States , Tim Gill , Eric Poeschla , Mamuka Kvaratskhelia , Gilead Sciences , Emory University , Division Of Infectious Diseases , Infectious Diseases , Colorado School , Nature Microbiology , Medicine Infectious Disease , Tim Gill Chair , ஒன்றுபட்டது மாநிலங்களில் , நேரம் கில் , கிலியட் அறிவியல் , உணர்ச்சி பல்கலைக்கழகம் , பிரிவு ஆஃப் தொற்று நோய்கள் , தொற்று நோய்கள் , கொலராடோ பள்ளி , இயற்கை நுண்ணுயிரியல் , மருந்து தொற்று நோய் ,