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Researchers identify surface protein as a new osteosarcoma therapeutic target for antibody-drug conjugates


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IMAGE: A preclinical study shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using.
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Credit: MD Anderson Cancer Center
Abstract #LB008
HOUSTON A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using precision therapy targeting of cell-surface proteins through a Bicycle toxin conjugate (BTC), shows encouraging results for the treatment of osteosarcoma. ....

United States , Gemma Mudd , Eric Earley , Rossana Lazcano Segura , Pooja Hingorani , Philip Huxley , Raushan Kurmasheva , Edwarda Kolb , Zhaohui Xu , Nemours Alfred , Johanna Lahdenranta , Alexander Lazar , Richard Gorlick , Sankaranarayanan Kannan , Wendong Zhang , Sylvester Jusu , Peter Houghton , Douglas Harrison , Stephen Erickson , Yifei Wang , Tara Gelb , Jonathan Gill , Malcolma Smith , Zhachui Xu , Jing Wang , Zhongting Zhang ,