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Using CRISPR, new technique makes it easy to map genetic networks


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CRISPR-Cas9 makes it easy to knock out or tweak a single gene to determine its effect on an organism or cell, or even another gene. But what if you could perform several thousand experiments at once, using CRISPR to tweak every gene in the genome individually and quickly see the impact of each?
A team of University of California, Berkeley, scientists has developed an easy way to do just that, allowing anyone to profile a cell, including human cells, and rapidly determine all the DNA sequences in the genome that regulate the expression of a specific gene.
While the technique will mostly benefit basic researchers who are interested in tracking the cascade of genetic activity the genetic network that impacts a gene they re interested in, it will also help researchers quickly find the regulatory sequences that control disease genes and possibly find new targets for drugs. ....

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