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BioAegis Therapeutics Unveils Upcoming Clinical Study of

BioAegis announces global Phase 2 study of its inflammation regulator protein, gelsolin, for the treatment of Acute Respiratory Distress Syndrome (ARDS). . ....

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Cancer Drug Cuts Inflammatory Response in Gout & Heart Diseases

PLK1 inhibitors are cancer drugs that help to treat inflammatory diseases by suppressing NLRP3 inflammasome , responsible for triggering immune response. ....

United Kingdom , University Of Cambridge , Plk1 Inhibitors , Cancer Drug , Lrp3 Inflammasome , Heart Failure , Nd Atrial Fibrillation ,

BioAegis Therapeutics Awarded $20 Million BARDA DRIVe

Partnership supports execution of a large phase 2 global study to evaluate efficacy and safety of recombinant human plasma gelsolin (rhu-pGSN) for. ....

Steven Cordovano , Christine Lagana , Susan Levinson , Division Of Research , Us Department Of Health , Bioaegis Therapeutics Inc , Development Authority , Administration For Strategic Preparedness , Biomedical Advanced Research , Society Vulnerability To Global Pandemics , Human Services , Aegis Therapeutics , Strategic Preparedness , Acute Respiratory Distress Syndrome , Reduce Society , Respiratory Distress Syndrome , Multitasking Protein , Complex Condition , Chief Executive Officer , Bioaegis Therapeutics , Lrp3 Inflammasome , Innate Immune System , Biotech Investing , L 1b ,

BioAegis Therapeutics to Sponsor a Webinar, Below the Eyes

Webinar will take place Tuesday, May 23, 2023 at 2:00 PM Eastern Time. ....

United States , Tufts University , Lester Kobzik , Markj Dinubile , Steven Cordovano , Joe Biden , Christine Lagana , David Fajgenbaum , Harvard Medical School , Public Health Schools , Hospital Of The University Pennsylvania , Yale School Of Medicine , Therapeutics Committee , Bioaegis Therapeutics Inc , Infectious Disease Society Of America , University Of Pennsylvania , Georgetown University , Cellecta Inc , Castleman Disease Collaborative Network , University Of Oxford , Merck Co Inc , Wharton School , Aegis Therapeutics , Expanding Spectrum , Chief Medical Officer , Bioaegis Therapeutics ,

Frontiers | Elevated NLRP3 Inflammasome Levels Correlate With Vitamin D in the Vitreous of Proliferative Diabetic Retinopathy

Abstract： Purpose: This study aims to determine vitamin D concentrations in the vitreous and serum, as well as the expression levels of NLRP3 inflammasome pathway in the vitreous of patients with proliferative diabetic retinopathy (PDR). In addition, we investigated the possible correlation between NLRP3 inflammasome levels and vitamin D concentrations. Methods: We obtained vitreous samples before vitrectomy from 55 PDR patients, 25 non-diabetic patients with idiopathic macular hole (IMH), and 10 nonproliferative diabetic retinopathy (NPDR) patients. We also collected serum samples from the same patients. Enzyme-linked immunosorbent assay (ELISA) was used to examine NLRP3 Iinflammasome pathway proteins, including NLRP3, caspase-1, IL-1β, and VEGF. In addition, vitamin D concentrations were analyzed in Roche Cobas 6000’s module e601 platform by electrochemiluminescence immune assay. Results: The levels of NLRP3 inflammasome pathway and VEGF increased dramatically in PDR vitreous. H ....

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