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Ivermectin Disappoints in Mild COVID-19


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COVID-19 patients treated in a randomized trial with the anti-parasitic drug ivermectin did no better than a placebo group, Colombian researchers said.
Median time to recovery among mild COVID-19 patients in the ivermectin group was 10 days versus 12 days among those receiving placebo, and rates of symptom resolution at day 21 were about equal, reported Eduardo López-Medina, MD, of Centro de Estudios en Infectología Pediátrica, and colleagues, writing in
But the trial was far from perfect. The initial primary outcome was time from randomization until worsening of symptoms by two points on an ordinal scale, but few patients reached this endpoint in the expected time, meaning the sample size needed to maintain sufficient power was unattainable. Therefore, the primary endpoint was changed to time from randomization to symptom resolution by day 21, and the original sample size was retained. ....

Molly Walker , Centro De Estudios , Aggressive Behavior , Musculoskeletal Pain , Muscle Pain , Loss Of Sense Smell , மாலீ வாக்கர் , சிஇஎன்டிஆர்ஓ டி ெஸ்த்துதிோஸ் , தசைக்கூட்டு வலி , தசை வலி , இழப்பு ஆஃப் உணர்வு வாசனை ,

How Long Do COVID Olfactory Problems Last?


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Sense of smell can be altered for 5 months or more after acute SARS-CoV-2 infection, Canadian researchers reported.
Nearly one in five healthcare workers who had a compromised sense of smell when they first were infected reported persistent olfactory changes 150 days later, said Johannes Frasnelli, MD, of the University of Quebec at Trois-Rivieres, and colleagues, in a preliminary report released in advance of the American Academy of Neurology annual meeting.
The findings are based on 813 Quebec healthcare workers who tested positive for SARS-CoV-and completed online questionnaires and home chemosensory tests an average of 5 months after diagnosis. Most participants (84%) were women. ....

France General , Poitou Charentes , United States , Judy George , Johannes Frasnelli , Nicolas Dupre , Jerome Lechien , Paris Saclay University , Laval University In Quebec City , University Of Quebec At Trois , American Academy Of Neurology , American Academy , Quebec Laval University , Quebec City , Medpage Today , Chemosensory Dysfunction Associated , Disorder Of Taste , Loss Of Sense Smell , Respiratory Tract Infection , Memory Impairment , பிரான்ஸ் ஜநரல் , ஒன்றுபட்டது மாநிலங்களில் , ஜூடி ஜார்ஜ் , நிக்கோலாஸ் துப்றெ , லாவள் பல்கலைக்கழகம் இல் க்வீபெக் நகரம் , பல்கலைக்கழகம் ஆஃப் க்வீபெக் இல் ட்ரோயிஸ் ,

For Some, COVID-19 Olfactory Dysfunction May Be Permanent


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Nearly one in four COVID-19 patients with olfactory dysfunction said they did not recover their sense of smell 60 days after losing it, a large prospective study in Europe showed.
Among nearly 2,600 people with confirmed SARS-CoV-2 infection, patient-reported prevalence of olfactory dysfunction was 85.9% in mild COVID-19 cases, 4.5% in moderate cases, and 6.9% in severe-to-critical cases, reported Jerome Lechien, MD, PhD, of Paris Saclay University in France, and co-authors in the
About 24% of patients did not subjectively recover olfaction 60 days after dysfunction started. When a smaller sample of patients was evaluated with objective olfactory tests, 15.3% still showed deficiency at 60 days and 4.7% had not recovered olfaction at 6 months. ....

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