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Alzheimer's risk gene undermines insulation of brain's "wiring" | MIT News | Massachusetts Institute of Technology

MIT research shows that in people carrying the APOE4 risk variant, a key brain cell type mismanages cholesterol needed to insulate neurons properly another sign that APOE4 contributes to Alzheimer's disease by disrupting lipids in the brain. ....

Martin Kahn , Chih Yu Chen , Cristina Blanco Duque , Manolis Kellis , Michael Bula , Eric Orlund , Lea Rbibo , Audrey Effenberger , Shawn Davidson , William Ralvenius , Hansruedi Mathys , Nicolas Lavoie , Kristan Maner Smith , Liwang Liu , Ricardo Reyes , David Bennet , Li Huei Tsai , Emre Agbas , Joel Blanchard , Jose Davila Velderrain , Xueqiao Jiang , Ihab Jahhar , Sinai Icahn School Of Medicine , Gene Ludwig Family Foundation , Department Of Brain , Cure Alzheimer Fund ,

Alzheimer's Risk Gene Undermines Insulation of Brain's 'Wiring'

When people carry the Alzheimer's associated APOE4 gene, oligodendrocytes fail to transport fatty molecules to wrap neurons that make brain circuitry connections. This deficit of myelin may contribute to the pathology and symptoms of Alzheimer's disease. ....

Martin Kahn , Cristina Blanco Duque , Manolis Kellis , Michael Bula , Eric Orlund , Lea Rbibo , Shawn Davidson , William Ralvenius , Hansruedi Mathys , Nicolas Lavoie , Kristan Maner Smith , Audrey Effenbergerchi , Liwang Liu , Ricardo Reyes , Li Huei Tsai , David Bennet , Emre Agbas , Joel Blanchard , Jose Davila Velderrain , Xueqiao Jiang , Ihab Jahhar , Sinai Icahn School Of Medicine , Cognitive Sciences , Tsai Laboratory , Brain Initiative , Picower Institute For ,

Alzheimer's risk gene undermines insulation of brain's "wiring"

Alzheimer's risk gene undermines insulation of brain's "wiring"
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Martin Kahn , Cristina Blanco Duque , Manolis Kellis , Michael Bula , Eric Orlund , Lea Rbibo , Shawn Davidson , William Ralvenius , Hansruedi Mathys , Nicolas Lavoie , Kristan Maner Smith , Audrey Effenbergerchi , Liwang Liu , Ricardo Reyes , Li Huei Tsai , David Bennet , Emre Agbas , Joel Blanchard , Jose Davila Velderrain , Xueqiao Jiang , Ihab Jahhar , Sinai Icahn School Of Medicine , National Insitutes , Cognitive Sciences , Brain Initiative , Picower Institute For ,